六君子汤加减方联合质子泵抑制剂治疗消化性溃疡活动期临床研究  

Clinical Study on Modified Liujunzi Decoction Combined with Proton Pump Inhibitor for Peptic Ulcer Disease in Active Stage

作　　者：郑菲 兰强芳 顾佳鲁 ZHENG Fei;LAN Qiangfang;GU Jialu

机构地区：[1]舟山市普陀区人民医院消化内科,浙江舟山316100

出　　处：《新中医》2023年第3期41-45,共5页New Chinese Medicine

摘　　要：目的:观察六君子汤加减方联合质子泵抑制剂治疗消化性溃疡活动期临床疗效。方法:选取94例消化性溃疡活动期患者,按随机数字表法分为对照组及观察组各47例。对照组给予质子泵抑制剂治疗,观察组在对照组基础上给予六君子汤加减方治疗。比较2组临床疗效及治疗后1年复发率,比较2组治疗前后中医证候积分、疼痛视觉模拟评分法(VAS)评分、临床症状、胃黏膜组织学评分及炎症因子水平[C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)]的变化,观察2组不良反应发生情况。结果:观察组临床疗效总有效率为93.62%,对照组临床疗效总有效率为78.72%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分及VAS评分均较治疗前下降(P<0.05),观察组中医证候积分及VAS评分均低于对照组(P<0.05)。观察组胃痛消失时间及溃疡愈合时间均早于对照组,差异均有统计学意义(P<0.05)。治疗后,2组炎性细胞浸润、炎症活动性、黏膜厚度、腺体密度、腺体形态的胃黏膜组织学评分均较治疗前下降(P<0.05),观察组各胃黏膜组织学评分均低于对照组(P<0.05)。治疗后,2组CRP、TNF-α、IL-6水平均较治疗前下降(P<0.05),观察组上述3项水平均低于对照组(P<0.05)。观察组复发率为9.30%,对照组复发率为34.29%,2组比较,差异有统计学意义(P<0.05)。结论:六君子汤加减方联合质子泵抑制剂治疗消化性溃疡活动期的临床疗效较好,能缓解患者临床症状,改善胃黏膜功能,降低机体炎症反应,且复发率低。Objective:To observe the clinical effect of the therapy of modified Liujunzi Decoction combined with proton pump inhibitor on peptic ulcer disease in the active stage.Methods:A total of 94 patients with peptic ulcer disease in the active stage were selected and divided into the control group and the observation group according to the random number table method,with 47 cases in each group.The control group was treated with proton pump inhibitor,and the observation group was additionally treated with modified Liujunzi Decoction on the basis of the treatment of the control group.The clinical effects and recurrence rate one year after treatment were compared between the two groups.The changes in the traditional Chinese medicine(TCM) syndrome scores,scores of Visual Analogue Scale(VAS),clinical symptoms,gastric mucosal histological scores and inflammatory factors,including C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6),before and after treatment were compared between the two groups.The incidence of adverse reactions in the two groups was also observed.Results:The total effective rate was 93.62% in the observation group and 78.72% in the control group,the difference being significant(P<0.05).After treatment,the TCM syndrome scores and VAS scores in both groups were decreased when compared with those before treatment(P<0.05),and the two scores in the observation group were lower than those in the control group(P<0.05).The disappearance time of stomachache and ulcer healing time in the observation group were shorter than those in the control group,differences being significant(P<0.05).After treatment,the levels of inflammatory cell infiltration,inflammatory activity,mucosal thickness,glandular density as well as the histological scores of gastric mucosae of glandular morphology in the two groups were decreased when compared with those before treatment(P<0.05),and the above gastric mucosal histological scores in the observation group were lower than those in the control group(P<0.05).Afte

关 键 词：消化性溃疡活动期 六君子汤 质子泵抑制剂 视觉模拟评分法 复发率 

分 类 号：R573.1[医药卫生—消化系统]