Topical ketotifen treatment for allergic conjunctivitis:a systematic review and Meta-analysis  

作　　者：Xin-Yan Dou Wei Zhang 

机构地区：[1]Department of Ophthalmology,Shanghai Wusong Central Hospital,Shanghai 200940,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第2期286-292,共7页国际眼科杂志（英文版）

摘　　要：AIM:To assess the efficacy of ketotifen in treating allergic conjunctivitis.METHODS:A systematic search of systematic reviews and Meta-analyses was conducted on the Pub Med and Web Science of Science until October 2021 to address this knowledge gap.Mean difference with 95%CI and P values were used to assess the efficacy of ketotifen.The heterogeneity(I^(2))was used to evaluate the impact of heterogeneity.RESULTS:Eight randomized controlled trials(RCTs)involving 1589 patients were included in this Meta-analysis.The results revealed that after treating with ketotifen,itching(MD=-0.91,95%CI:-1.63 to-0.20,I^(2)=94%,P=0.01),tearing(MD=-0.40,95%CI:-0.61 to-0.18,I^(2)=75%,P=0.0003)and total signs and symptoms(MD=-0.85,95%CI:-1.12 to-0.58,I2=0,P<0.00001)showed better benefit effect compared to the placebo group.CONCLUSION:Topical ketotifen is an effective treatment for patients with allergic conjunctivitis.

关 键 词：allergic conjunctivitis KETOTIFEN META-ANALYSIS OLOPATADINE 

分 类 号：R777.31[医药卫生—眼科]