丁苯酞联合丹参多酚治疗缺血性脑卒中的疗效及对患者认知功能的影响  

Efficacy of butylphthalide combined with salvianolic acid on ischemic stroke and its effects on cognitive function of patients

作　　者：罗昊辉 王小蓉[2] 袁勇[1] 刘炳东[1] LUO Hao-hui;WANG Xiao-rong;YUAN Yong;LIU Bing-dong(Department of Pharmacy,Ya'an People's Hospital,Ya'an 625000,Sichuan,China;Department of Geriatrics,Ya'an People's Hospital,Ya'an 625000,Sichuan,China)

机构地区：[1]雅安市人民医院药剂科,四川雅安625000 [2]雅安市人民医院老年科,四川雅安625000

出　　处：《川北医学院学报》2023年第2期237-240,共4页Journal of North Sichuan Medical College

摘　　要：目的:研究丁苯酞联合丹参多酚治疗缺血性脑卒中(IS)的疗效及对患者认知功能的影响。方法:回顾性分析110例IS患者的临床资料,根据治疗方法不同分为丹参多酚组(n=55,丁苯酞联合丹参多酚治疗)和丁苯酞组(n=55,丁苯酞治疗)。比较两组治疗4周后的治疗效果、中医症候积分、认知功能(MoCA评分)、血清炎性因子[白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、神经元特异性烯醇化酶(NSE)]水平。结果:治疗后,两组患者有效率比较,差异无统计学意义(P>0.05);两组中医症候积分与血清TNF-α、NSE水平均降低(P<0.05),MoCA评分、血清IL-10水平均升高(P<0.05),且两组间上述指标比较,差异均具有统计学意义(P<0.05)。结论:丁苯酞联合丹参多酚治疗IS效果较显著,能够有效改善临床症状及认知功能,降低机体炎症水平。Objective:To study the efficacy of butylphthalide combined with salvianolic acid on ischemic stroke(IS) and its effects on cognitive function of patients.Methods:The clinical data of 110 patients with IS were retrospectively analyzed.According to different treatment methods, the patients were divided into salvianolic acid group(n=55,butylphthalide combined with salvianolic acid treatment) and butylphthalide group(n=55,butylphthalide treatment).The treatment effects, TCM symptoms scores, cognitive function(MoCA score)and inflammatory factors [interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),neuron specific enolase(NSE)] were compared between the two groups after 4 weeks of treatment.Results:After 4 weeks of treatment, there was no statistically significant difference in the effective rate between the two groups(P>0.05).The TCM symptoms scores and levels of TNF-α and NSE were decreased in both groups(P<0.05),while the MoCA score and level of IL-10 were increased(P<0.05),and the above indexes showed significant differences between the groups(P<0.05).Conclusion:Butylphthalide combined with salvianolic acid has good effects in the treatment of IS,and can effectively improve clinical symptoms and cognitive function, and reduce the body inflammation level.

关 键 词：缺血性脑卒中 丹参多酚 丁苯酞 临床疗效 认知功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]