原发性腮腺淋巴瘤的病理特征及预后影响因素  

Pathological Features and Prognostic Factors of Primary Parotid Lymphoma

作　　者：张又之 梁倩楠 任婷婷 马春艳 李慧娜 卢泰青 杜娟 ZHANG Youzhi;LIANG Qiannan;REN Tingting(Henan Stomatological Hospital,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,河南省口腔医院,450000

出　　处：《实用癌症杂志》2023年第3期462-464,共3页The Practical Journal of Cancer

摘　　要：目的 分析原发性腮腺淋巴瘤(PPL)的病理特征及预后影响因素。方法 96例PPL患者,根据患者病情给予局部治疗及系统治疗,于治疗结束后随访3年,统计患者生存情况,并分为生存组和死亡组。收集患者一般资料,分析病理特征,采用单因素和Logistic回归分析PPL预后的影响因素。结果 96例PPL患者中,仅有1例霍金淋巴瘤(HL),其余95例为非HL(NHL),其中结外边缘区黏膜相关淋巴组织淋巴瘤(MALT)、弥漫性大B细胞淋巴瘤(DLBCL)为常见病理类型,分别占PPL的45.26%、32.63%;病理特征:MALT淋巴瘤肿瘤细胞核小至中等大小,略不规则,细胞质淡染,肿瘤细胞在正常腺体周围增殖,大部分病例可见明显淋巴结上皮病变;DLBCL肿瘤细胞体积大,细胞质淡染、丰富,细胞核体积较大;治疗结束后随访3年,96例患者中有58例生存,占比60.42%,38例死亡,占比39.58%。两组性别、年龄、原发位置、临床Ann Arbor分期、局部症状、近期肿物加速生长病史、存在B症状比较,差异无统计学意义(P>0.05);死亡组术后吸烟、血清LDH水平异常升高、肿瘤最大直径大、肿瘤无包膜高于生存组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,术后吸烟、伴血清LDH水平异常升高、肿瘤最大直径大、肿瘤无包膜比率均是影响PPL预后的独立危险因素。结论 血清LDH水平异常升高、肿瘤最大直径大、肿瘤无包膜均是影响PPL预后的独立危险因素,临床应给予高度重视。Objective To analyze primary parotid lymphoma(PPL) pathological characteristics and prognostic factors.Methods 96 patients with PPL were retrospectively analyzed.They were given local treatment and systematic treatment according to their condition.After treatment, they were followed up for 3 years, counted their survival, and divided into survival group and death group.The general data of patients were collected, the pathological characteristics were analyzed, and univariate and logistic regression analysis were used The prognostic factors of PPL were analyzed by regression.Results Among 96 patients with ppl, There was only 1 case of Hawking lymphoma(HL),and the other 94 cases were non HL(NHL),including extranodal marginal mucosa associated lymphoid tissue lymphoma(MALT) and diffuse large B-cell lymphoma(DLBCL) was a common pathological type, accounted for 45.26% and 32.63% of PPL respectively;pathological features: MALT lymphoma had small to medium-sized nuclei, slightly irregular cytoplasm, light staining, tumor cells proliferate around normal glands, and obvious lymph node epithelial lesions can be seen in most cases;DLBCL had large tumor cells, light staining and abundant cytoplasm, and large nuclear volume.After 3 years of follow-up, 58 of the 96 patients survived, accounted for 60.42%,and 38 died, accounted for 39.58%.Gender, age, primary location, clinical Ann Arbor stage, local symptoms, recent history of accelerated tumor growth and presence of B symptoms were compared between the 2 groups, There was no significant difference(P>0.05);the postoperative smoking, abnormal increase of serum LDH level, large maximum diameter of tumor and non capsule ratio of tumor in the death group were significantly higher than those in the survival group(P<0.05);multivariate logistic regression analysis showed that postoperative smoking, abnormal increase of serum LDH level, large tumor maximum diameter and tumor non capsule ratio were independent risk factors affecting the prognosis of PPL.Conclusion Abnormal increase of

关 键 词：原发性腮腺淋巴瘤 病理特征 预后 影响因素 

分 类 号：R733.4[医药卫生—肿瘤]