乳腺原发性鳞状细胞癌16例临床病理分析  

Primary squamous cell carcinoma of the breast: a clinicopathological analysis of 16 cases

作　　者：李嘉 原玉芬[1] 杨海军[1] LI Jia;YUAN Yu-fen;YANG Hai-jun(Department of Pathology,Anyang Tumor Hospital,Anyang,Henan 455 China)

机构地区：[1]安阳市肿瘤医院病理科,河南安阳455000

出　　处：《诊断病理学杂志》2022年第11期1008-1011,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的 探讨乳腺原发性鳞状细胞癌(PSCC)的临床病理特征,诊断及鉴别诊断,治疗及预后。方法 回顾性分析16例乳腺PSCC的临床病理资料。结果 16例乳腺PSCC均为女性,年龄35~82岁,均龄54.1岁。肿物直径1~9 cm,平均3.4 cm, 9例实性(56%),7例为囊实性(44%)。组织学多为角化型和非角化型,4例可见梭形细胞形态,2例见棘层松解形态。肿瘤多为中、低分化,伴有明显坏死及炎细胞浸润。免疫组化2例ER及1例PR低表达,其余均(-);Ki-67增殖指数较高。HER-2 5例阳性,阳性率5/16(31.2%)。腋窝淋巴结有6例转移,转移率6/16(37.5%)。13例获得随访,3例术后发生肺转移,其中2例死亡。结论 乳腺PSCC是罕见的乳腺癌亚型,肿瘤通常体积较大,常见囊性成分,组织学分级高,免疫组化不表达或弱表达激素受体,HER-2可呈阳性表达。淋巴结转移率较低。肿瘤侵袭性强,易发生远处转移。Objective To investigate the clinicopathological features, diagnosis and differential diagnosis, treatment and prognosis of primary squamous cell carcinoma(PSCC) of the breast. Methods The clinicopathological data of 16 cases of breast PSCC were analyzed retrospectively. Results 16 cases of breast PSCC were female, aged 35-82 years old, average age was 54.1 years old. The diameter of the tumor ranged from 1 cm to 9 cm, with an average of 3.4 cm. 9 cases were solid(56%) and 7 cases were cystic(44%). Histologically, most of them were keratinized and non keratinized. Spindle cell morphology was seen in 4 cases and spinous layer lysis morphology was seen in 2 cases. Most of the tumor are moderately and poorly differentiated, with varying degrees of keratosis, accompanied by obvious necrosis and inflammatory cell infiltration. Immunohistochemical staining showed low expression of ER in 2 cases and PR in 1 case, and the rest were(-);The positive index of Ki-67 was 20% ~90%, with an average of 50%. HER-2 was positive in 5 cases, and the positive rate was 5/16(31.2%). There were 6 cases of axillary lymph node metastasis, and the metastasis rate was 6/16(37.5%). 13 cases were followed up, of which 3 cases had lung metastasis and 2 cases died. Conclusion breast PSCC is a rare subtype of breast cancer. The tumor is usually large in volume and common in cystic components. Its histological grade is high. Immunohistochemistry can not express or weakly express hormone receptors, and HER-2 can be positive. The rate of lymph node metastasis is low. The tumor is invasive and prone to distant metastasis.

关 键 词：乳腺肿瘤 鳞状细胞癌 原发性 病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]