血脂异常、胃泌素-17、幽门螺旋杆菌在不同病理类型胃息肉中的表达及关联性  

Expression and correlation of dyslipidemia, gastrin-17 and Helicobacter pylori in different pathological types of gastric polyps

作　　者：张伟[1] 徐斌[1] 鲁明 ZHANG Wei;XU Bin;LU Ming(Department of Gastroenterology,The First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui,China,232000)

机构地区：[1]安徽理工大学第一附属医院消化内科,安徽淮南232000

出　　处：《分子诊断与治疗杂志》2023年第2期249-252,256,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省中医药传承创新科研(2022CCZD08)。

摘　　要：目的 探讨血脂异常、胃泌素-17(G-17)、幽门螺旋杆菌(Hp)在不同病理类型胃息肉中的表达及关联性。方法 选取2020年1月至2022年6月的104例于淮南市第一人民医院消化内科确诊为胃肠道息肉的患者作为试验组,选取同期经胃镜检查诊断为非萎缩性胃炎104名作为胃炎组,并根据试验组患者的胃息肉的病理类型将试验组分为增生性胃息肉组(n=57)、胃底腺胃息肉组(n=29)、炎性胃息肉组(n=14)、腺瘤性胃息肉组(n=4)。比较各组血脂异常的病例数、G-17水平以及各组的Hp感染病例数,分析血脂异常、G-17、幽门螺旋杆菌与不同病理类型胃息肉的相关性。结果 试验组的血脂异常率以及Hp感染率明显高于胃炎组,且试验组的G-17表达水平明显高于胃炎组,差异具有统计学意义(χ^(2)=5.308、6.252,t=10.943,P<0.05)。不同病理类型胃息肉的血脂异常率、G-17表达水平以及Hp感染率比较:胃底腺胃息肉组<炎性胃息肉组<增生性胃息肉组<腺瘤性胃息肉组,差异有统计学意义(χ^(2)=11.740、13.647,F=57.313,P<0.05)。多因素Logistic回归分析显示,血脂异常、G-17以及Hp阳性为胃息肉病情进展的独立危险因素,ROC曲线分析显示,血脂异常、G-17以及幽门螺杆菌以及联合检测预测胃息肉病理类型对应的AUC为0.710、0.827、0.836、0.911。结论 血脂异常、G-17水平以及幽门螺旋杆菌与胃息肉的病理类型具有一定的相关性,三者联合检测对胃息肉的病情进程具有较高的预测价值。Objective To investigate the expression and correlation of dyslipidemia,gastrin⁃17(G⁃17)and Helicobacter pylori(Hp)in different pathological types of gastric polyps.Methods 104 patients diagnosed with gastrointestinal polyps in the Department of Gastroenterology,Huainan First People􀆳s Hospital from January 2020 to June 2022 were selected as the experimental group,and 104 patients diagnosed with non⁃atrophic gastritis by gastroscopy during the same period were selected as the gastritis group.According to the pathological types of gastric polyps,the experimental groups were divided into the hyperplastic gastric polyps group(n=57),the fundus glandular gastric polyps group(n=29),the inflammatory gastric polyps group(n=14)and the adenomatous gastric polyps group(n=4).The number of cases of dyslipidemia,the level of G⁃17 and the number of Hp infection in each group were compared,and the correlation between dyslipidemia,G⁃17 and Helicobacter pylori and different pathological types of gastric polyps was analyzed.Results The dyslipidemia rate and Hp infection rate in the experimental group were significantly higher than those in the gastritis group,and the level of G⁃17 in the experimental group was significantly higher than that in the gastritis group,the difference was statistically significant(χ^(2)=5.308,6.252,t=10.943,P<0.05).Comparison of dyslipidemia rate,G⁃17 expression level and Hp infection rate among different pathological types of gastric polyps was as follows:gastric basement glandular polyp group<inflammatory gastric polyp group<proliferative gastric polyp group<adenomatous gastric polyp group,the differences were statistically significant(χ^(2)=11.740,13.647,F=57.313,P<0.05).Multivariate Logistic regression analysis showed that dyslipidemia,G⁃17 and Hp positive were independent risk factors for the progression of gastric polyps.ROC curve analysis showed that the AUCs of dyslipidemia,G⁃17,Helicobacter pylori and combined test for pathological types of gastric polyps were 0.710,0.827,0.

关 键 词：血脂异常 胃泌素-17 幽门螺杆菌 胃息肉 病理类型 

分 类 号：R573[医药卫生—消化系统]