钟基因Bmal1在颞下颌关节骨关节炎中的作用机制  

Mechanism of clock gene Bmal1 in temporomandibular joint osteoarthritis

作　　者：杜晨丹 都冰丽 宁潇 宗明锐 李冰[1] 武秀萍[1] Du Chendan;Du Bingli;Ning Xiao;Zong Mingrui;Li Bing;Wu Xiuping(Shanxi Key Laboratory of Prevention and Treatment of Oral Diseases and New Materials,School and Hospital of Stomatology,Shanxi Medical University,Taiyuan 030000,Shanxi Province,China)

机构地区：[1]山西医科大学口腔医学院·口腔医院,口腔疾病防治与新材料山西省重点实验室,山省太原市030000

出　　处：《中国组织工程研究》2023年第32期5227-5231,共5页Chinese Journal of Tissue Engineering Research

基　　金：山西省回国留学人员科研资助项目(HGKY2019-055),项目负责人:李冰;中央引导地方科技发展资金(科技成果转移转化)项目(YDZJSX2021C01),项目负责人:武秀萍;山西省教育厅科技创新资助项目(2020L0211),项目负责人:都冰丽。

摘　　要：背景:颞下颌关节骨关节炎是口腔科常见疾病,其发病机制复杂,近来发现时钟基因Bmal1表达减少可以导致小鼠颞下颌关节发生骨关节炎样病理改变,但Bmal1在颞下颌关节骨关节炎中的作用机制尚不清楚。目的:总结钟基因Bmal1在颞下颌关节骨关节炎发生发展中可能的作用机制,为颞下颌关节骨关节炎的发病机制提供新思路。方法:检索中国知网、PubMed、Web of Science数据库建库至2022年的文献,中文检索词为“颞下颌关节骨关节炎,骨关节炎,颞下颌关节紊乱病,髁突软骨,Bmal1,昼夜节律,生物钟,睡眠”,英文检索词为“TMJOA,osteoarthritis,TMD,condylar cartilage,Bmal1,circadian rhythms,circadian clock,sleep”,根据纳入和排除标准,共纳入50篇文章进行分析总结。结果与结论:①睡眠剥夺引起的昼夜节律紊乱可以导致小鼠颞下颌关节发生骨关节炎样病理改变,暗示昼夜节律紊乱是诱发颞下颌关节骨关节炎发生的新的危险因素;②Bmal1作为昼夜节律的核心时钟因子,在维持颞下颌关节软骨内稳态方面发挥重要作用;③当Bmal1表达减少时关节软骨的合成代谢减少、分解代谢增加,髁突软骨降解,诱发颞下颌关节骨关节炎;Bmal1过表达可以缓解骨关节炎的病理症状;④Bmal1也可以通过下游信号通路影响髁突软骨的软骨形成和软骨内骨化,使髁突及下颌骨发育不良,为颞下颌关节骨关节炎的发生发展提供解剖基础;⑤同时Bmal1还可以通过调控氧化应激、脂肪代谢等促进机体衰老和肥胖,从而增加颞下颌关节骨关节炎的发病风险;⑥因此时钟基因Bmal1可能通过直接和/或间接作用在颞下颌关节骨关节炎的发生发展中发挥作用。BACKGROUND:Temporomandibular joint osteoarthritis is a common disease in stomatology and its pathogenesis is complex.Recently,it has been found that the decreased expression of clock gene Bmal1 can lead to osteoarthritis-like pathological changes of the temporomandibular joint in mice,but the mechanism of Bmal1 in temporomandibular joint osteoarthritis remains unclear.OBJECTIVE:To summarize the possible mechanism of clock gene Bmal1 in the development of temporomandibular joint osteoarthritis,so as to provide new insights into the pathogenesis of temporomandibular joint osteoarthritis.METHODS:Articles published from inception to 2022 were retrieved in PubMed,Web of Science,and CNKI by the keywords of“TMJOA,osteoarthritis,TMD,condylar cartilage,Bmal1,circadian,circadian clock,sleep”in English and Chinese.Fifty articles were finally selected for this review according to the criteria of inclusion and exclusion.RESULTS AND CONCLUSION:Circadian rhythm disturbance caused by sleep deprivation can lead to osteoarthritis-like pathological changes of the temporomandibular joint in mice,suggesting that circadian rhythm disturbance is a new risk factor for temporomandibular joint osteoarthritis.As a core clock factor of circadian rhythm,Bmal1 plays an important role in maintaining cartilage homeostasis of the temporomandibular joint.When Bmal1 expression is decreased,anabolism of the articular cartilage is decreased,catabolism is increased,condylar cartilage is degraded,and temporomandibular joint osteoarthritis is induced.Bmal1 overexpression can alleviate the pathological symptoms of osteoarthritis.Bmal1 can also affect chondrogenesis and endochondral ossification of the condyle cartilage through downstream signaling pathways,resulting in dysplasia of the condyle and mandible,which provides an anatomical basis for the occurrence and development of temporomandibular joint osteoarthritis.At the same time,Bmal1 can promote aging and obesity by regulating oxidative stress and fat metabolism,thereby increasing the susceptib

关 键 词：昼夜节律 BMAL1 颞下颌关节骨关节炎 髁突软骨 衰老 肥胖 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R782.6