二硫化钼纳米材料在生物传感器中的应用  

Application of Molybdenum Disulfide Nanomaterials in Biosensors

作　　者：房文汇[1] 张昱 翟英娇 李金华[1] 徐铭泽[1] FANG Wen-Hui;ZHANG Yu;ZHAI Ying-Jiao;LI Jin-Hua;XU Ming-Ze(Nanophotonics and Biophotonics Key Laboratory of Jilin Province,Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing,School of Physics Changchun University of Science and Technology,Changchun 130022,China)

机构地区：[1]长春理工大学物理学院,教育部跨尺度微纳制造重点实验室,吉林省纳米光子学与生物光子学重点实验室,长春130022

出　　处：《生物化学与生物物理进展》2023年第2期189-207,共19页Progress In Biochemistry and Biophysics

基　　金：教育部“111”创新引智项目(D17017);吉林省教育厅项目(JJKH20220723KJ);国家自然科学基金(62174015)资助。

摘　　要：近年来纳米材料的不断引入,为生物传感技术提供了新的研究途径,大大提高了生物传感器的性能。其中,二硫化钼(MoS_(2))纳米材料由于比表面积大、带隙可调、电子迁移率高等独特性质,在生物传感器中被广泛应用。本文首先介绍了基于MoS_(2)纳米材料的电化学、场效应晶体管、表面增强拉曼散射、比色、双模式生物传感器的基本原理、研究进展及性能对比,重点分析了MoS_(2)纳米复合材料的结构、组分等对传感器灵敏度、检测范围、检测限、特异性等性能的影响,总结了MoS_(2)生物传感器的优势并对其未来发展趋势进行了展望,为MoS_(2)生物传感器在生物检测领域的进一步应用以及未来研究方向提供了思路。In recent years, nanomaterials have provided a new research approach for biosensor technology and greatly improved the performance of biosensor. Molybdenum disulfide(MoS_(2)) nanomaterials have been widely used in biosensors due to their unique properties such as large specific surface area, adjustable band gap and high electron mobility. This paper introduces electrochemical, field effect transistor(FET), surface-enhanced Raman scattering(SERS), colorimetric method and dual-mode biosensor based on MoS_(2)nanomaterials. Among them,MoS_(2)electrochemical biosensor uses the redox reaction between target and biological probe to analyze the concentration of target. It has the advantages of high sensitivity, fast response speed and simple operation, but its experimental cost is high, so low-cost experimental methods need to be developed in the future. When MoS_(2)acts on FET, it is used as the channel material to contact the analyte, and the gate applies bias voltage to realize the current change. It is small in size and high in sensitivity, but there are few reports on the detection of biomolecules in actual human samples. Therefore, it is necessary to focus on solving the problem of compatibility between sensor and biological solution in the future. MoS_(2)nanocomposite SERS biosensor can be combined with chemical enhancement and electromagnetic enhancement to achieve singlemolecule detection. Its sample consumption is small and no special treatment is required, but the large-scale optical analysis system of its detection process is complex and expensive. Therefore, the simplification of optical analysis equipment and detection system is a problem to be further studied. MoS_(2)nanocomposite colorimetric biosensor utilizes its peroxidase activity to catalyze the color change of the chromogenic substrate. It has the advantages of easy operation and low cost, but its sensitivity is not high and the reaction time is long. Therefore, in the future, it is necessary to find high-performance MoS_(2)nanomaterials to achieve

关 键 词：二硫化钼 生物传感器 生物分子检测 

分 类 号：O469[理学—凝聚态物理] Q67[理学—电子物理学] Q631[理学—物理]