腰骶穴区铺灸联合常规疗法治疗湿热内蕴型轻、中度活动期溃疡性结肠炎临床研究  

Clinical Study on Long-Snake Moxibustion at Point Areas in Lumbosacral Spine Combined with Routine Therapy for Ulcerative Colitis of Damp-Heat Accumulation Type at Mild or Moderate Active Period

作　　者：张爱军 陈一鹏 冀子中 陈峰 韩丰 万里 蔡陈效 章燕红 江彬 ZHANG Aijun;CHEN Yipeng;JI Zizhong;CHEN Feng;HAN Feng;WAN Li;CAI Chenxiao;ZHANG Yanhong;JIANG Bin

机构地区：[1]嘉兴市第一医院,浙江嘉兴314000

出　　处：《新中医》2023年第4期152-157,共6页New Chinese Medicine

基　　金：嘉兴市科技计划项目(2019AD32243);浙江省陈峰名老中医专家传承工作室(GZS2021037)。

摘　　要：目的:观察腰骶穴区铺灸治疗湿热内蕴型轻、中度活动期溃疡性结肠炎(UC)的临床疗效。方法:将纳入研究的70例患者按随机数字表法分为观察组与对照组,2组均予现代医学常规治疗,观察组加予腰骶穴区铺灸治疗,2组均连续治疗2个疗程。治疗前后评定症状积分,检测血清白细胞介素-23(IL-23)、白细胞介素-17(IL-17),统计治疗2个疗程后1个月内、3个月内的再发率,比较2组临床疗效,开展安全性评价。结果:治疗2个疗程后,2组主要症状积分、症状总积分均较治疗前减少(P<0.05);观察组腹泻、腹胀积分及症状总积分均低于对照组(P<0.05)。2组血清IL-23、IL-17水平均较治疗前降低(P<0.05);观察组血清IL-23、IL-17水平均低于对照组(P<0.05)。观察组临床疗效总有效率、再发率及不良反应发生率均与对照组相近,2组比较,差异均无统计学意义(P>0.05)。结论:腰骶穴区铺灸联合现代常规疗法治疗湿热内蕴型轻、中度活动期UC能提高临床疗效,与单纯实施常规治疗相比,能更为有效地改善临床症状,减轻肠道的炎症程度。Objective:To observe the clinical effect of long-snake moxibustion at point areas in lumbosacral spine for ulcerative colitis(UC)of damp-heat accumulation type at mild or moderate active period.Methods:A total of 70 cases of UC patients included in the study were divided into the observation group and the control group according to the random number table method.Both groups were treated with routine modern medicine,and the observation group was additionally treated with long-snake moxibustion at point areas in lumbosacral spine.Both groups were treated for 2 consecutive courses of treatment.Before and after treatment,the symptom scores were evaluated,and interleukin-23(IL-23)and interleukin-17(IL-17)in serum were detected.The recurrence rates within 1 month and 3 months after2 courses of treatment were counted,the clinical effects in the two groups were compared,and the safety evaluation was carried out.Results:After 2 courses of treatment,the scores of main symptoms and the total scores of symptoms in the two groups were decreased when compared with those before treatment(P<0.05);the scores of diarrhea and abdominal distension and the total score of symptoms in the observation group were lower than those in the control group(P<0.05).The levels of IL-23 and IL-17 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-23 and IL-17 in serum in the observation group were lower than those in the control group(P<0.05).The total effective rate of clinical effect,the recurrence rate and incidence of adverse reactions in the observation group were similar to those in the control group,there being no significant difference between the two groups(P>0.05).Conclusion:Compared with simply routine treatment,the application of long-snake moxibustion at point areas in lumbosacral spine combined with routine modern medicine for UC of damp-heat accumulation type at mild or moderate active period improves the clinical effects,and can improve clinical symptoms and reduce inte

关 键 词：溃疡性结肠炎 湿热内蕴证 铺灸 白细胞介素-23 白细胞介素-17 

分 类 号：R574.62[医药卫生—消化系统]