神经内镜经鼻蝶扩大入路切除鞍结节脑膜瘤的临床疗效  

Clinical Effect of Neuroendoscopic Transsphenoidal Extended Approach for Resection of Tuberculum Sellae Meningioma

作　　者：郭爱顺 林镇荣 王熠喆 汪伟巍 林瑞生 Guo Aishun;Lin Zhenrong;Wang Yizhe;Wang Weiwei;Lin Ruisheng(The Department of Neurosurgery,Zhangzhou Hospital Affiliated to Fujian Medical University)

机构地区：[1]福建医科大学附属漳州市医院,福建漳州363000

出　　处：《医疗装备》2023年第5期96-99,共4页Medical Equipment

摘　　要：目的 分析神经内镜经鼻蝶扩大入路切除鞍结节脑膜瘤的临床疗效及安全性。方法 选取2017年1月至2021年1月福建医科大学附属漳州市医院收治的56例鞍结节脑膜瘤患者为研究对象,根据治疗方式的不同分为对照组(28例)和试验组(28例)。对照组开展常规手术治疗,试验组开展神经内镜经鼻蝶扩大入路切除术治疗,比较两组临床疗效、不良反应发生情况、神经功能缺损程度、血清炎症因子指标及生命质量改善情况。结果 试验组肿瘤切除总有效率高于对照组,差异有统计学意义(P<0.05);试验组不良反应发生率低于对照组,差异有统计学意义(P<0.05);术后1、3 d,试验组格拉斯哥昏迷评分量表(GCS)评分高于对照组,差异有统计学意义(P<0.05);术后3 d,试验组白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)等血清炎症因子指标低于对照组,差异有统计学意义(P<0.05);试验组心理功能、生理功能、环境、社会功能评分高于对照组,差异有统计学意义(P<0.05)。结论 采取神经内镜经鼻蝶扩大入路切除术治疗鞍结节脑膜瘤患者可提升临床疗效,降低不良反应发生率,并改善患者的神经功能、血清炎症因子指标及生命质量。Objective The clinical efficacy and safety of neuroendoscopic transsphenoidal extended approach in the resection of tuberculum sellae meningiomawere analyzed.Methods From January 2017 to January 2021,56 patients with tuberculum sellae meningioma treated in Zhangzhou Hospital Affiliated to Fujian Medical University were selected as the research objects.According to the treatment methods,they were divided into control group(28 cases) and observation group(28cases).The control group received routine surgical treatment,and the observation group received neuroendoscopic transsphenoidal extended resection.The efficacy,adverse reactions,neurological deficit,serum inflammatory factor index level and quality of life of patients with sellar tubercle meningioma were compared between the two groups.Results The total effective rate of tumor resection in the test group was higher than that in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the test group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The GCS score of the observation group at 1 and 3 days after operation was higher than that of the reference group and the control group,and the difference was statistically significant(P<0.05).The serum inflammatory factor indexes such as IL-4,IL-6,TNF-α,hs-CRP in the observation group 3 days after operation were lower than those in the reference group and the control group,and the difference was statistically significant(P<0.05).The scores of psychological function,physiological function,environment and social function in the observation group were higher than those in the control group,and the difference was statistically significant(P < 0.05).Conclusion The treatment of tuberculum sellae meningioma by neuroendoscopic transsphenoidal extended approach can improve the clinical efficacy,reduce the incidence of adverse reactions,and improve the neurological function,serum inflammatory factor index and quality

关 键 词：鞍结节脑膜瘤 经鼻蝶扩大入路切除术 内镜 神经功能 

分 类 号：R739.45[医药卫生—肿瘤]