自身免疫性癫痫早期诊断和治疗的研究进展  

Research progress on the early diagnosis and treatment of autoimmune epilepsy

作　　者：魏良豪 魏伟 狄晴[1] WEI Liang-hao;WEI Wei;DI Qing(Department of Neurology,Brain Hospital Affliated to Nanjing Medical Universiy,Nanjing 210029,China)

机构地区：[1]南京脑科医院神经内科,210029

出　　处：《临床神经病学杂志》2022年第6期473-477,共5页Journal of Clinical Neurology

摘　　要：随着近十余年来对自身免疫性癫痫(AE)认识的不断加深,免疫已成为癫痫不可忽视的病因。越来越多的研究表明免疫治疗对AE效果十分显著,早期诊断和免疫治疗与其良好预后相关。神经特异性自身抗体检测是诊断AE的关键检查,但其较高的检测费用并不适合作为普查手段,因此明确具有何种特征的癫痫患者需要进行相关抗体检测,对于早期诊断和早期治疗AE具有重要意义。本文将围绕AE相关的临床线索、诊断原则、传统治疗和免疫治疗等方面进行综述,以供临床医生和今后研究参考。With the continuous deepening of understanding of autoimmune epilepsy(AE) in the past ten years, immunity has become a cause of epilepsy that cannot be ignored. More and more studies have shown that immunotherapy has a significant effect on AE, and early diagnosis and immunotherapy are related to its good prognosis. Neural specific autoantibodies testing is a critical examination for diagnosing AE, but its high testing cost is not suitable as a general screening method. Therefore, it is great significance for early diagnosis and early treatment of AE to determine the characteristics of epilepsy patients who need relevant antibody detection. This article reviews the clinical clues, diagnostic principles, traditional treatment and immunotherapy related to AE to provide reference for clinicians and future research.

关 键 词：癫痫 自身免疫性 诊断 神经特异性自身抗体 免疫治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学]