基于供体-受体原理构建的共价有机框架材料用于癌症的光热治疗  

A donor-acceptor covalent organic framework as the promising construct for photothermal therapy

作　　者：万秀艳 张洁 左凯明 张惠文 胡慧 潘伟 高艳安 李娜 唐波 Xiuyan Wan;Jie Zhang;Kaiming Zuo;Huiwen Zhang;Hui Hu;Wei Pan;Yanan Gao;Na Li;Bo Tang(College of Chemistry,Chemical Engineering and Materials Science,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong,Institute of Molecular and Nano Science,Shandong Normal University,Jinan 250014,China;Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources,Hainan University,Haikou 570228,China)

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong,Institute of Molecular and Nano Science,Shandong Normal University,Jinan 250014,China [2]Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources,Hainan University,Haikou 570228,China

出　　处：《Science China Materials》2023年第3期1227-1236,共10页中国科学（材料科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22104074,22274089,and 21965011);the Natural Science Foundation of Shandong Province(ZR2022YQ10 and ZR2020QB106);the Local Science and Technology Development Fund Guided by the Central Government(YDZX20203700002568);the Natural Science Foundation of Hainan Province(220RC458);the Major Science and Technology Plan of Hainan Province(ZDKJ202016).

摘　　要：我们设计合成了一例共价有机框架材料(TB-COF),并将其开发应用为癌症的光热治疗试剂.TB-COF是基于供体-受体原理,由富电子构建单元(供体)和缺电子构建单元(受体)构建而成.当受到激光照射时,TB-COF中供体和受体之间会发生显著的光诱导电子转移,将吸收的光能转化为热能并用于肿瘤消融.TB-COF具有优异的光热转换效率,其值可达43.65%,与常用的光热试剂相当.此外,我们还将透明质酸(HA)包覆在TB-COF上,以提高其生物相容性并实现肿瘤靶向功能.体外和体内实验均证实了TB-COF-HA高效的光热抗癌功能.A donor-acceptor covalent organic framework(COF), TB-COF, constructed from an electron-rich building unit(donor) and an electron-deficient building unit(acceptor), was developed as a promising photothermal agent for photothermal therapy(PTT). Upon laser irradiation, significant photoinduced electron transfer(PET) occurs between the donor and acceptor in TB-COF, converting the absorbed optical energy to thermal energy and resulting in the ablation of tumor. TB-COF possessed satisfying photothermal conversion efficiency, reaching 43.65%, similar to materials commonly used for PTT. Moreover, hyaluronic acid(HA) was coated on TB-COF to improve its biocompatibility and achieve tumor targeting. Furthermore, in vitro and in vivo experiments confirmed satisfying photothermal anticancer efficacy of TB-COF-HA.

关 键 词：光热治疗 光诱导电子转移 肿瘤靶向 抗癌功能 光能转化 生物相容性 设计合成 体内实验 

分 类 号：R730.5[医药卫生—肿瘤] TB383.4[医药卫生—临床医学]