外阴阴道念珠菌病致病菌种分布及流行特征分析  

Distribution of pathogenic yeast species of vulvovaginitis and its epidemiological characteristics

作　　者：周益花 邓淑文 张璐 张虹 赵蓉芬 王玉凤 孙艳霞 朱卉[2] ZHOU Yihua;ZHU Hui;ZHANG Lu;ZHANG Hong;ZHAO Rongfen;WANG Yufeng;DENG Shuwen;SUN Yanxia(The People’s Hospital of Suzhou New District,Suzhou 215129,China;The First Affiliated Hospital of Soochow University,Suzhou 215008,China)

机构地区：[1]苏州高新区人民医院,苏州215129 [2]苏州大学附属第一医院,苏州215008

出　　处：《中国真菌学杂志》2023年第1期12-18,共7页Chinese Journal of Mycology

摘　　要：目的阐明外阴阴道念珠菌病(VVC)致病菌种分布及流行特征。方法收集VVC致病菌1083株,分子鉴定(D1/D2)至菌种水平,回顾性收集VVC患者临床信息,分析不同致病菌种所致VVC临床特征。结果白念珠菌为主要致病菌种(71.38%),非白念珠菌(NAC)占28.62%,其中,光滑念珠菌占19.02%。20~40岁、已婚、妊娠为VVC危险因素,孕期更易感染NAC。NAC致复发性VVC高于白念珠菌。结论对VVC患者常规分泌物培养、菌种水平鉴定,结合体外药敏结果,对临床医生制定有效治疗方案具有重要参考价值。Objective To investigate the epidemiological characteristics of vulvovaginitis caused by different yeast spp.Methods Totally 1083 yeast isolates were collected from patients with vulvovaginal candidiasis(VVC).These isolates were identified to the species level according to the genes of 26S rRNA D1/D2 domain.The clinical characteristics VVC cases caused by these different species were analyzed.Results The results showed that Candida albicans remain the prodominent species(71.38%)causing VVC,while Non-candida albicans(NAC)account for 28.62%among which C.glabrata account for 19.02%.The risk factors included 20-40 years of age,being married,and pregnancy.NACs were more often isolated in pregnant women.The incidence of recurrent vaginal candidiasis caused by non-albicans Candida were higher.Conclusion Routine culture of secretion from VVC patients,molecular identification to species level of VVC causative agents,and identification of non-albicans Candida species would help clinicians to explore an effective therapy for VVC.

关 键 词：VVC 流行特征 酵母菌 分子鉴定 抗真菌治疗 

分 类 号：R519.3[医药卫生—内科学]