地塞米松植入剂研究进展(综述)  

Research progress of dexamethasone implants

作　　者：李德明[1] 赵亮 宣凤琴[1] LI De-ming;ZHAO Liang;XUAN Feng-qin(College of environment and life health,Anhui Vocational and Technical College,Hefei 230011,Anhui;Hefei Zhongren Technology Co.Ltd.,Hefei 230051,Anhui;Controlled Release Drug Laboratory,Hefei University of Technology,Hefei 230051,Anhui)

机构地区：[1]安徽职业技术学院环境与生命健康学院,安徽合肥230011 [2]合肥中人科技有限责任公司,安徽合肥230051 [3]合肥工业大学控释药物研究室,安徽合肥230051

出　　处：《安徽医专学报》2023年第1期88-91,共4页Journal of Anhui Medical College

基　　金：安徽省教育厅自然科学重点项目(编号:KJ2019A0986)。

摘　　要：植入型给药系统(植入剂)具有生物利用度高,直接作用于靶部位,延长作用时间以提高患者顺应性等特点。地塞米松是一种经典的抗炎、免疫抑制药物,但传统的给药方式会引起一些副作用。因此,开发地塞米松植入剂对提高疗效和用药安全性具有重要意义。该文就地塞米松植入剂在几类疾病治疗中的应用和研究进展进行综述,为开发地塞米松植入剂提供参考。Implantable drug delivery systems(implants)are characterized by high bioavailability,direct action on the target site,prolonged action time to improve patient compliance,etc.Dexamethasone is a classic antiinflammatory and immunosuppressive drug,but the traditional way of administration can cause some side effects.Therefore,the development of dexamethasone implants is of great significance to improve the efficacy and drug safety.In this review,the application and research progress of dexamethasone implants in the treatment of several diseases were reviewed,providing reference for the development of dexamethasone implants.

关 键 词：植入剂 地塞米松 药物载体 药物治疗 给药系统 

分 类 号：R774[医药卫生—眼科]