Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation  

作　　者：Ying Wang Jixian Wang Qing-Fang Zhang Ke-Wei Xiao Liang Wang Qing-Ping Yu Qing Xie Mu-Ming Poo Yunqing Wen 

机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai,200031,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China [4]Department of Rehabilitation Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China [5]Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Lingang Laboratory,Shanghai,201210,China

出　　处：《Neuroscience Bulletin》2023年第1期69-82,共14页神经科学通报（英文版）

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32070100);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Shanghai Key Basic Research Project(18JC1410100);Lingang Lab(LG202106-04-03 and LG202105-01-07);the Shanghai Pilot Program for Basic Research–Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-010).

摘　　要：The optimal protocol for neuromodulation by transcranial direct current stimulation(tDCS)remains unclear.Using the rotarod paradigm,we found that mouse motor learning was enhanced by anodal tDCS(3.2 mA/cm^(2))during but not before or after the performance of a task.Dual-task experiments showed that motor learning enhancement was specific to the task accompanied by anodal tDCS.Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner.Transcranial in vivo Ca^(2+)imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex(M1).Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance,suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning enhancement.Thus,application of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.

关 键 词：Motor learning tDCS effect Neural mechanism of tDCS Neuronal excitability Stroke model mouse 

分 类 号：R741[医药卫生—神经病学与精神病学]