环境化学研究中的质谱方法  

Mass Spectrometry for Environmental Chemistry Research

作　　者：余明月 魏奶杰 严晓文[1] 陈石[1] 陈建彬[1] 杨利民[1] 王秋泉[1] YU Ming-yue;WEI Nai-jie;YAN Xiao-wen;CHEN Shi;CHEN Jian-bin;YANG Li-min;WANG Qiu-quan(Department of Chemistry&the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China)

机构地区：[1]厦门大学化学化工学院化学系,谱学分析与仪器教育部重点实验室,福建厦门361005

出　　处：《质谱学报》2023年第2期170-180,共11页Journal of Chinese Mass Spectrometry Society

摘　　要：研究环境化学及与其相关的生命科学,对了解环境污染和生命物种的暴露程度,以及由此引发的健康问题非常必要。这一过程中,质谱是不可或缺的强有力工具。本文简要介绍了基于质谱的相关方法在环境化学研究中的应用。概括地强调了电感耦合等离子体质谱(ICP-MS)、电子捕获负化学源质谱(ECNI-MS)、电喷雾离子化质谱(ESI-MS)、基质辅助激光解吸电离质谱(MALDI-MS)以及高分辨串联质谱(HR-MS)、非变性质谱(nMS)和质谱成像(MSI)技术对环境和生命介质中污染物的分析鉴定,及其对正常生命过程的扰动机制研究所发挥的作用;并展望了质谱技术在环境化学中的发展趋势,指出了反应蛋白组学的发展和具有污染物分子及其代谢产物的反应性官能团分子标尺的设计,深化对污染物分子及其代谢产物与关键生物分子相互作用的理解,加深对环境污染健康效应的认识。Studies of environmental chemistry and its related life science are essential to understand the exposure of environmental pollution to living species and the resulted health problems.During this process,mass spectrometry is an indispensably powerful tool thanks to its qualitative and quantitative abilities and remarkable mass resolution.In this review,the state-of-the art mass spectrometric methods were introduced,including inductively coupled plasma mass spectrometry(ICP-MS),electron capture negative ionization mass spectrometry(ECNI-MS),electrospray ionization mass spectrometry(ESI-MS),matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS),high-resolution tandem mass spectrometry(HR-MS)and native mass spectrometry(nMS)as well as mass spectrometry imaging(MSI),which have been applied in environmental chemistry and the related life science research,with an emphasis on their role in the determination,characterization,discovery and biological impacts research of environmental pollutants in the environmental media,and the related metabolites during life process.Furthermore,the trend of MS methods from fundamental to applied perspectives was outlooked,in order to solve the emerging issues,such as the ambiguous interaction mechanisms of the environmental pollutants and/or their metabolites with biomolecules.It is very much expected that novel MS-based strategy like reactive proteomics approach together with the design of new molecular ruler will help to solve the“mystery”of the environmental pollutants and/or their biological metabolites impacted on a normal physiological process,deepening our understanding on the influence of environmental pollution on health.

关 键 词：质谱 环境污染 健康 分析鉴定 分子机制 

分 类 号：O657.63[理学—分析化学]