蚕丝基葡萄糖传感器研究进展  

Research progress on silk-based glucose sensors

作　　者：王怡[1,2,3] 汪宇佳 陈方春 王雅思 代方银[1,2,3] 李智[1,2,3,4] WANG Yi;WANG Yujia;CHEN Fangchun;WANG Yasi;DAI Fangyin;LI Zhi(State Key Laboratory of Silkworm Genome Biology,Southwest University,Chongqing 400715,China;College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing 400715,China;Chongqing EngineeringResearch Center of Biomaterial Fiber and Modern Textile,Southwest University,Chongqing 400715,China;Key Laboratory ofFlexible Devices for Intelligent Textile and Apparel,Soochow University,Suzhou 215123,China)

机构地区：[1]西南大学家蚕基因组生物学国家重点实验室,重庆400715 [2]西南大学蚕桑纺织与生物质科学学院,重庆400715 [3]西南大学重庆市生物质纤维材料与现代纺织技术研究中心,重庆400715 [4]苏州大学纺织行业智能纺织服装柔性器件重点实验室,江苏苏州215123

出　　处：《丝绸》2023年第3期8-15,共8页Journal of Silk

基　　金：重庆市教育委员会科学技术研究项目(KJQN202100203);纺织行业智能纺织服装柔性器件重点实验室开放课题资助项目(SDHY2111);重庆市留创计划创新类资助项目(cx2019090);家蚕基因组生物学国家重点实验室开放课题资助项目(sklsgb-2019KF13)。

摘　　要：葡萄糖传感器是糖尿病人监控血糖浓度的必备工具。基于柔性基底开发可用于实时监测的柔性葡萄糖传感器是近年来研究的热点,也是未来应用发展的重要方向。蚕丝具有优异的力学性能、生物相容性及生物可降解性,以蚕丝及蚕丝蛋白与导电活性物质复合开发的柔性葡萄糖传感器展现出优异的传感性能及出色的长期稳定性。本文通过对基于丝蛋白、丝纤维、蚕丝织物开发的蚕丝基葡萄糖传感器的研究进展进行综述,对比所开发的蚕丝基葡萄糖传感器的传感性能,分析其特点及作用机制,并展望蚕丝基葡萄糖传感器在柔性可穿戴传感器领域的发展前景。Glucose sensors,as a tool for diabetics to monitor blood glucose,are of great significance in the diagnosis and treatment of diabetes.With the rapid development of flexible smart wearable devices,the development of glucose sensors based on flexible substrate has also gradually become a research hotspot.Silk has good biocompatibility,degradability and flexibility,its surface is rich in chemical bonds such as carboxyl,hydroxyl and amide bonds which can interact with active substances,and it is a good conductive substrate material.The flexible glucose sensor developed by using silk and silk fibroin as the substrate,and by being compounded with conductive active materials has excellent sensing performance and good long-term stability.This article aims to review the research progress of silk-based glucose sensors developed based on silk fibroin,silk fiber and silk fabric,analyze their characteristics and mechanism,and prospect their development tendency.In order to fully understand the application of silk in the field of glucose sensors,this paper starts with the development of glucose sensors,and focuses on the research progress of silk-based glucose sensors on basis of two main kinds of silk and silk fibroin.We first introduced the characteristics and properties of silk,and discussed the application of silk yarns,silk fabrics and carbonized silk fabrics in the field of glucose sensors.Then,we summarized the application of fibroin films and spun fibers based on silk fibroin in the field of glucose sensors.By reviewing the preparation methods and sensing performance of various silk-based glucose sensors,we analyzed the role of silk in them,and summarized the effect of the silk substrate on the glucose sensing performance.It is hoped that this paper can provide a reference for the design and development of high-performance silk-based flexible glucose sensors.Glucose sensors based on silk fabrics have better mechanical properties,higher conductivity and sensitivity,while those made of silk fibroin have better biocompati

关 键 词：蚕丝 丝素蛋白 蚕丝织物 葡萄糖传感器 葡萄糖氧化酶 柔性电子器件 

分 类 号：TS141.8[轻工技术与工程—纺织材料与纺织品设计]