肝X受体在阿尔茨海默病发病机制中的研究进展  

The role of LXRs in the pathogenesis of Alzheimer’s disease:a review

作　　者：刘贺琼 马超颖 郭会彩(综述)[1,2] 王磊 刘诣(审校)[1,2] LIU Heqiong;MA Chaoying;GUO Huicai;WANG Lei;LIU Yi(School of Public Health,Hebei Medical University,Shijiazhuang,Hebei 050017,China;Hebei Key Laboratory of Environment and Human Health,Shijiazhuang,Hebei 050017,China;Hebei Medical University,Shijiazhuang,Hebei 050017,China)

机构地区：[1]河北医科大学公共卫生学院,河北石家庄050017 [2]河北省环境与人群健康重点实验室,河北石家庄050017 [3]河北医科大学,河北石家庄050017

出　　处：《预防医学》2023年第3期215-217,223,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：国家自然科学基金(82073681);河北省自然科学基金(B2020206008,H2020206584);河北省省级科技计划资助(19274801D);河北省教育厅重点项目(ZD2019044)。

摘　　要：阿尔茨海默病(AD)是一种以β淀粉样蛋白沉积为特征的神经退行性疾病。肝X受体(LXRs)是核受体转录因子超家族的一员,在大脑中广泛表达,可能参与AD的发生发展。本文检索2010—2022年LXRs与AD发病相关的国内外研究文献,围绕LXRs在AD发病机制中参与调控胆固醇代谢、炎症反应和突触形成的研究进展进行综述,为AD防制提供理论依据。Alzheimer’s disease(AD)is a neurodegenerative disease characterized by deposition ofβ-amyloid(Aβ).Liver X receptors(LXRs),a member of the nuclear receptor transcription factor superfamily,are widely expressed in brain,which may be involved in the development and progression of AD.Based on the international and national publications pertaining to the association between LXRs and AD from 2010 to 2022,this review summarizes the advances on the involvement of LXRs in the regulation of cholesterol metabolism,inflammatory response and synapse formation in the pathogenesis of AD was reviewed,so as to provide insights into the prevention and treatment of AD.

关 键 词：肝X受体 阿尔茨海默病 胆固醇代谢 炎症反应 突触形成 

分 类 号：R749.16[医药卫生—神经病学与精神病学]