肠镜检查人群多靶点粪便DNA检测意愿的影响因素分析  

Willingness and influencing factors of multitarget stool DNA testing among individuals receiving colonoscopy screening

作　　者：吕乐彬 樊金卿 赵王芳 陆启文[2] 顾俊娣 高菡璐 Lü Lebin;FAN Jinqing;ZHAO Wangfang;LU Qiwen;GU Jundi;GAO Hanlu(Medical School of Ningbo University,Ningbo,Zhejiang 315000,China;The Affiliated Hospital of Medical School,Ningbo University,Ningbo,Zhejiang 315000,China)

机构地区：[1]宁波大学医学院,浙江宁波315000 [2]宁波大学医学院附属医院,浙江宁波315000

出　　处：《预防医学》2023年第3期218-223,共6页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：浙江省医药科技计划项目(2021KY1048,2022KY1142);宁波市卫生健康青年技术骨干人才培养专项(2020SWSQNGG-02);宁波市重大科技任务攻关项目(2021Z133)。

摘　　要：目的 分析肠镜检查人群多靶点粪便DNA (MT-sDNA)检测接受意愿和支付意愿的影响因素,为结直肠癌筛查策略制定和卫生经济学评价提供依据。方法 选择2021年8月—2022年3月在宁波大学医学院附属医院进行肠镜检查的40~75岁人群为调查对象,通过问卷调查收集基本信息、生活行为、家族史、MT-sDNA检测接受意愿和支付意愿等资料,采用多因素logistic回归模型分析MT-sDNA检测接受意愿和支付意愿的影响因素。结果 调查546人,年龄为(56.25±8.66)岁;男性282人,占51.65%。愿意接受MT-sDNA检测504人,占92.31%;愿意支付MT-sDNA检测费用480人,占88.24%。多因素logistic回归分析结果显示:有一级亲属结直肠癌家族史(OR=0.246,95%CI:0.068~0.888)、有痔疮史(OR=0.300,95%CI:0.109~0.826)的肠镜检查人群MT-sDNA检测接受意愿较低;认可MT-sDNA检测可靠性(OR=5.749,95%CI:1.480~22.323)、认为MT-sDNA检测取样没有困难(OR=32.042,95%CI:6.666~154.021)和有一定难度(OR=20.278,95%CI:4.405~93.354)的肠镜检查人群MT-sDNA检测接受意愿较高;认可(OR=5.003,95%CI:1.761~14.216)和担心(OR=4.166,95%CI:1.285~13.501) MT-sDNA检测可靠性、认为MT-sDNA检测取样没有困难(OR=6.558,95%CI:2.105~20.428)和有一定难度(OR=5.820,95%CI:1.810~18.720)的肠镜检查人群MT-sDNA检测支付意愿较高。结论 一级亲属结直肠癌家族史、痔疮史和MT-sDNA检测的认知程度是肠镜检查人群MT-sDNA检测接受意愿和支付意愿的影响因素。Objective To investigate the willingness to receiving multitarget stool DNA (MT-sDNA) testing and factors affecting the payment among individuals receiving colonoscopy screening,so as to provide the evidence for the formula-tion and health economic evaluation of colorectal cancer screening strategies.MethodsIndividuals at ages of 40 to 75years that received colonoscopy screening in The Affiliated Hospital of Ningbo University Medical School from August2021 to March 2022 were sampled.Participants’demographics,living behaviors,family history,willingness to receive MT-sDNA testing and willingness to pay for MT-sDNA testing were collected using questionnaire surveys,and factors affecting the willingness to receive and pay for MT-sDNA testing were analyzed using a multivariable logistic regression model.ResultsA total of 546 respondents were enrolled,with a mean age of (56.25±8.66) years and including 282men (51.65%).There were 504 respondents that were willing to receiving MT-sDNA testing (92.31%) and 480 that were willing to pay for the MT-sDNA testing (88.24%).Multivariable logistic regression analysis showed that a family history of colorectal cancer in first-degree relatives (OR=0.246,95%CI:0.068-0.888),history of hemorrhoids (OR=0.300,95%CI:0.109-0.826) resulted in low willingness to receive MT-sDNA testing,and recognizing the reliability of MT-sDNA testing (OR=5.749,95%CI:1.480-22.323),considering no difficulty in sampling for MT-sDNA testing (OR=32.042,95%CI:6.666-154.021) and considering a difficulty in sampling for MT-sDNA testing (OR=20.278,95%CI:4.405-93.354) resulted in high willingness to receive MT-sDNA testing,while recognizing the reliability of MT-sDNA testing(OR=5.003,95%CI:1.761-14.216),concern about the reliability of MT-sDNA testing (OR=4.166,95%CI:1.285-13.501),considering no difficulty in sampling for MT-sDNA testing (OR=6.558,95%CI:2.105-20.428) and considering a difficul-ty in sampling for MT-sDNA testing (OR=5.820,95%CI:1.810-18.720) resulted in high willingness to pay for the MT-sDNA tes

关 键 词：结直肠癌 多靶点粪便DNA检测 肠镜检查 

分 类 号：R735.3[医药卫生—肿瘤]