基于气血津液理论探讨铁死亡与急性放射性食管炎的相关性  

Correlation Between Ferroptosis and Acute Radiation-induced Esophagitis from TCM Theory of Qi, Blood and Body Fluid

作　　者：郇瑞华 汪欣文[2] 李欣雨 HUAN Ruihua;WANG Xinwen;LI Xinyu(Shanxi University of Chinese Medicine,Taiyuan Shanxi China 030024;Research Institute of Shanxi Hospital of Traditional Chinese Medicine,Taiyuan Shanxi China 030012)

机构地区：[1]山西中医药大学,山西太原030024 [2]山西省中医药研究院,山西太原030012

出　　处：《中医学报》2023年第3期453-459,共7页Acta Chinese Medicine

基　　金：山西省医学科技创新团队建设项目(2020TD04);山西省卫生计生委科研课题项目(2017095);山西省中医药管理局科研课题项目(2022ZYYZ010)。

摘　　要：急性放射性食管炎是放疗引起的一种无菌性炎症。铁死亡作为一种铁依赖的、脂质过氧化产物大量堆积的独特程序性细胞死亡方式,其抑制剂能够发挥抗炎作用,而放疗作为一种外源性诱导剂,能加快铁死亡的进程。适度的铁死亡维持着机体的平衡稳态,而铁死亡过度发生时则会造成机体一系列炎症等不良反应,这与中医的气血津液理论有很重要的联系。气血津液作为构成人体生命活动的基本要素,其运行失常与急性放射性食管炎的发生密切相关,因此,维持机体气血津液的正常运行是防治急性放射性食管炎的重要前提。Acute radiation esophagitis is a kind of aseptic inflammation caused by radiotherapy.Ferroptosis, being an iron-dependent, unique programmed cell death mode with a large accumulation of lipid peroxidation products, its inhibitor can play an anti-inflammatory role.While radiotherapy, as an exogenous inducer, can accelerate the process of iron death, moderate iron death maintains the balance and stability of the body, while excessive iron death will cause a series of adverse reactions such as inflammation, which is closely related to the theory of Qi, blood and body Fluid in traditional Chinese medicine.As the basic element of human life activities, the abnormal operation of Qi, blood and body Fluid is closely related to the occurrence of acute radiation esophagitis.Therefore, maintaining the normal operation of Qi, blood and body Fluid is an important prerequisite for the prevention and treatment of acute radiation esophagitis.

关 键 词：急性放射性食管炎 铁死亡 气血津液 

分 类 号：R223.14[医药卫生—中医基础理论]