超声介导微泡破坏在抗肿瘤血管治疗中的研究进展  

Research Progress of Ultrasound-Mediated Microbubble Destruction in Antivascular Tumor Therapy

作　　者：李翔宇 卢漫 Li Xiangyu;Lu Man(School of Medical Imaging,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Ultrasound Medical Center,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China)

机构地区：[1]川北医学院医学影像学院,四川南充637000 [2]四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院超声医学中心,成都610041

出　　处：《肿瘤预防与治疗》2023年第2期168-176,共9页Journal of Cancer Control And Treatment

基　　金：国家重点研发项目(编号:2019YFE0196700)。

摘　　要：肿瘤通过新生血管来获得足够的氧气和营养,因此直接抑制肿瘤脉管系统的抗血管疗法在肿瘤治疗领域占据重要地位。抗血管疗法针对现有或正在生成的肿瘤血管,降低血流灌注以抑制肿瘤的生长。超声介导微泡破坏(ultrasound-targeted microbubble destruction,UTMD)通过其特有的生物学效应调控血管内皮细胞(endothelial cells,EC)进行抗血管治疗,可打破药物摄取的血管屏障并改变肿瘤微环境,增强常规抗肿瘤血管疗法的效果。在这篇综述中,我们论述了UTMD空化效应抗血管的机制,介绍了超声微泡与抗血管生成疗法相结合的研究进展,例如超声空化介导的EC凋亡效应以及UTMD协同增强放化疗的抗血管效应,为其在肿瘤治疗中的研究和应用提供参考。Tumors receive adequate oxygen and nutrients through neovascularization,so antivascular therapy that directly inhibits tumor vasculatures plays an important role in the field of tumor therapy.Antivascular therapy targets existing or emerging tumor vasculatures,and reduces blood perfusion to inhibit tumor growth.The unique biological effect of ultrasound-targeted microbubble destruction(UTMD)can modulate vascular endothelial cells(EC)for antivascular therapy,breaking the vascular barrier for drug uptake and altering the tumor microenvironment to enhance the effect of conventional antivascular therapy.In this review,we discuss the mechanism of the cavitation effect of UTMD on antiangiogenisis activity,and introduce the research progress of ultrasound microbubbles combined with antiangiogenic therapy,such as the apoptotic effect of EC mediated by ultrasound cavitation and the enhancement of the antivascular effect of UTMD in conjunction with chemoradiotherapy,so as to provide evidence for research and application of UTMD in tumor treatment.

关 键 词：超声微泡 肿瘤血管生成 抗血管治疗 空化效应 

分 类 号：R730.5[医药卫生—肿瘤]