脑部淋巴系统解剖及其与阿尔茨海默病关系的研究进展  

The process in research of anatomy of brain lymphatic system and the relationship between it and Alzheimer's disease

作　　者：李旭博(综述) 汪华侨[2,3] 顾立强(审阅) LI Xubo;WANG Huaqiao;GU Liqiang(Department of Microsurgery,Orthopeadic Trauma,and Hand Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Department of Anatomy and Physiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Editorial Board of Chinese Journal of Microsurgery,Guangzhou 510062,China)

机构地区：[1]中山大学附属第一医院显微创伤手外科,广州510080 [2]中山大学中山医学院解剖生理学系,广州510080 [3]《中华显微外科杂志》编辑部,广州5100

出　　处：《中华显微外科杂志》2022年第6期710-717,共8页Chinese Journal of Microsurgery

摘　　要：传统观念认为中枢神经系统(CNS)不存在淋巴管或淋巴循环,缺乏清除大脑代谢物的淋巴途径。但随着对颅内清除的深入研究,人们发现CNS中存在类淋巴系统,包括胶质淋巴通路以及脑膜淋巴管,从而进一步揭示了脑脊液(CSF)与间质液(ISF)的交换体系,而且其与许多神经退行性疾病、与年龄相关的大脑变化、创伤性脑损伤、循环系统疾病和肿瘤等发生发展密切相关。近10年来,有关其研究是生命科学的热点,本文旨在从类淋巴系统的发现、解剖结构及功能、与阿尔茨海默病(AD)的关系几个方面阐述其相关研究进展。Conventional wisdom holds that the central nervous system(CNS)does not have lymphatic vessels or lymphatic circulation,and it lacks lymphatic pathways to clear brain metabolites.However,with the development of study in intracranial clearance,it has been discovered that there are lymphatic systems in CNS,including glymphatic pathway and it meningeal lymphatic vessels.It further reveals the exchange system between cerebrospinal fluid(CSF)and interstitial fluid(ISF).It also closely relates to the development of neurodegenerative diseases,age-related changes of brain,traumatic brain injury,circulatory diseases and tumors.In the past 10 years,the research in CNS has been a hot spot in life sciences.This article aims to explain the research progress from the aspects of the discovery of glymphatic system,anatomical structure and function,and relationship with Alzheimer's disease(AD).

关 键 词：类淋巴系统 淋巴系统 脑膜淋巴管 中枢神经系统 淋巴循环 阿尔茨海默病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]