PGⅠ/PGⅡ比值在青年胃癌患者诊断价值研究  

Diagnostic Value of PGⅠ/PGⅡ Ratio in Young Patients with Gastric Cancer

作　　者：陈少华[1] 张倩[1] 孙永梅 李明[1] CHEC Shaohua;ZHANG Qian;SUN Yongmei;LI Ming(Department of Laboratory Diagnostics of the First Affiliated Hospital,University of Science and Technology of China,Hefei Anhui 230031,China)

机构地区：[1]中国科学技术大学附属第一医院检验科,安徽合肥230032

出　　处：《安徽理工大学学报（自然科学版）》2022年第6期103-108,共6页Journal of Anhui University of Science and Technology:Natural Science

基　　金：安徽省自然科学基金资助项目(2008085MH288)。

摘　　要：目的 研究不同年龄分层下常见胃癌血清肿瘤标志物的临床诊断价值。方法 选取2017a 1月至2020a 12月在安徽省肿瘤医院住院治疗的90例胃癌患者为研究对象,按年龄进行分组,青年组(18~40岁)25例,中老年组(≥41岁)65例,同时采用体检中心健康体检人员作为对照组。胃癌患者及健康对照人员,均采用罗氏Cobas601电化学发光法进行血清肿瘤标志物(CA724、CEA、CA199、FERR)检测和荧光免疫层析法进行PGⅠ、PGⅡ的检查并计算PGⅠ/PGⅡ比值,分析这6种肿瘤标志物对两组患者的诊断效率。结果 PGⅠ/PGⅡ比值是不同年龄段人群胃癌发生的独立影响因素,PGⅡ是中老年组人群胃癌发生的独立影响因素;PGⅠ/PGⅡ诊断胃癌发生的曲线下面积(AUC)在青年组、中老年组中分别为0.826 7、0.894 7,Cutoff值分别为PGⅠ/PGⅡ<8.515和PGⅠ/PGⅡ<8.16。传统的血清肿瘤标志物CA724、CEA、CA199、FERR均不是所有年龄段人群胃癌发生的独立影响因素,其对胃癌患者的诊断价值不高。结论 PGⅠ/PGⅡ比值可作为青年胃癌早期筛查指标。Objective To study the clinical diagnostic value of common gastric cancer serum tumor markers in different age groups. Methods A total of 90 gastric cancer patients hospitalized in Anhui Cancer Hospital from January 2017 to December 2020 were selected as the research objects and grouped by age, the youth group: 18 to 40 years old, 25 cases;the middle-aged and elderly group: ≥41 years old, 65 cases, with the healthy people from the physical examination center used as the control group. Serum tumor markers CA724, CEA, CA199, FERR were detected by Roche Cobas 601 electrochemiluminescence method, and PGⅠ, PGⅡ were detected by fluorescence immunochromatography and the ratio of PGⅠ/PGⅡ was calculated. The diagnostic efficiency of these six tumor markers for the two groups of patients was analyzed. Results PGⅠ/PGⅡ ratio was an independent influencing factor of gastric cancer occurrence in different age groups, and PGⅡ was an independent influencing factor of gastric cancer occurrence in middle-aged and elderly people;the area under the curve(AUC) of PGⅠ/PGⅡ in diagnosing gastric cancer occurrence was 0.826 7 and 0.894 7 in youth and middle-aged and elderly groups, and the Cutoff values were PGⅠ/PGⅡ<8.515 and PGⅠ/PGⅡ<8.16, respectively. Traditionally, the serum tumor markers CA724, CEA, CA199, and FERR are not the independent influencing factors for the occurrence of gastric cancer in all age groups, and have no diagnostic value for gastric cancer patients. Conclusion The ratio of PGⅠ/PGⅡ can be used as an early screening index for gastric cancer in young group.

关 键 词：胃癌 年龄分层 胃蛋白酶原 青年 诊断价值 

分 类 号：R735.2[医药卫生—肿瘤]