牙周致病菌与结直肠癌关系的研究进展  

Research progress on the relationship between periodontal pathogens and colorectal cancer

作　　者：鲜文攀 任彪[2] 程磊[1] XIAN Wenpan;REN Biao;CHENG Lei(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙体牙髓病科,四川成都610041 [2]口腔疾病研究国家重点实验室、国家口腔疾病临床医学研究中心、四川大学华西口腔医院,四川成都610041

出　　处：《口腔疾病防治》2023年第7期513-517,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金面上项目(82071106);四川省科技计划项目(2020YJ0227)。

摘　　要：随着对口腔微生物与系统性疾病相关性研究的不断深入,研究者们发现牙周炎与糖尿病、心血管疾病和消化系统疾病等全身性疾病密切相关。具核梭杆菌(Fusobacterium nucleatum,Fn)和牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)是常见的牙周致病菌,二者在牙周炎的发生、发展过程中发挥着关键的作用,目前也有研究发现Fn和Pg与结直肠癌(colorectal cancer,CRC)的发生发展有着密切的关系,二者可以通过多种途径影响CRC的发生发展和CRC患者治疗效果及预后,包括通过调控细胞分裂周期和抑制细胞凋亡促进肿瘤细胞增殖、抑制免疫细胞功能介导免疫逃逸及肿瘤转移、营造适合肿瘤生存的促炎微环境等。通过疫苗研发、免疫制剂和抗生素使用等途径更好地预防、治疗结直肠癌和改善结直肠癌患者的预后。With the deepening of the research on the relationship between oral microbiota and systemic diseases,researchers have found that periodontitis is closely related to diabetes,cardiovascular disease,digestive system disease and other systemic diseases.Fusobacterium nucleatum(Fn)and Porphyromonas gingivalis(Pg)are common periodontal pathogens,which play a key role in the occurrence and development of periodontitis.At present,it is also found that Fn and Pg are closely related to the occurrence and development of colorectal cancer(CRC).They can affect the occurrence and development of CRC and the therapeutic effect and prognosis of CRC patients through a variety of ways.It can promote tumor cell proliferation by regulating cell division cycle and inhibiting cell apoptosis,inhibit immune cell function to mediate immune escape and tumor metastasis,and create a pro-inflammatory microenvironment suitable for tumor survival.The study of the effect of periodontal pathogens on the occurrence and development of colorectal cancer and its mechanism also allows us to think about new methods,such as vaccine development,immune agents and antibiotic use to better prevent and treat colorectal cancer and improve the prognosis of patients with colorectal cancer.

关 键 词：具核梭杆菌 牙龈卟啉单胞菌 牙周炎 结直肠癌 肿瘤发生 免疫逃逸 肿瘤微环境 肿瘤预后 

分 类 号：R78[医药卫生—口腔医学]