原花青素在深龋的治疗及修复中的应用进展  

Application of proanthocyanidin in the treatment and repair of deep caries

作　　者：高颖[1] 王珏 陶璐 姚经经 喻锦铃 黄晗丹 杨柳青 刘志辉[1] GAO Ying;WANG Jue;TAO Lu;YAO Jingjing;YU Jinling;HUANG Handan;YANG Liuqing;LIU Zhihui(Department of Prosthodontics,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院修复科,吉林长春130021

出　　处：《口腔疾病防治》2023年第7期518-523,共6页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：吉林省发展和改革委员会产业技术研究与开发项目(2021C043-2);吉林省教育厅科学技术研究项目(JJKH20211212KJ);吉林省科技发展计划项目(20200708127YY);吉林省科技发展计划项目(20210401149YY);吉林省财政厅科技项目(JCSZ2021893-9);长春市科技发展计划项目(21ZGY01)。

摘　　要：原花青素(proanthocyanidin,PA)是一种天然植物类多酚。由于PA具有促进再矿化、诱导胶原交联、抑制蛋白酶活性、抗菌等多种生物学作用,使其在治疗及修复深龋的临床应用中有着广阔的应用前景,例如促进牙本质再矿化、改善树脂-牙本质粘接效果、改善牙本质酸蚀效果等。首先,PA不仅能通过其自身或与其他再矿化剂联合促进牙本质再矿化,同时它还具有抗菌作用,在减少致龋病原菌及其生物膜形成的同时能够抑制其产酸,基于以上特性,PA能够减少龋病的发生,进而改善深龋治疗后的远期效果。此外,将PA加入到粘接剂或酸蚀剂中,利用其诱导胶原交联、抑制蛋白酶活性等生物学作用,能够改善对牙本质的酸蚀及粘接效果,继而达到改善深龋修复效果的最终目的。本文归纳总结了近年来PA在深龋的治疗及修复等方面的相关研究进展,从促进牙本质再矿化、抗菌和改善牙本质的粘接及酸蚀效果四个方面进行综述,以期能为临床深龋的治疗及修复提供更全面的参考。Proanthocyanidin(PA),as a kind of natural plant polyphenol,have a variety of biological functions,such as promoting remineralization,inducing collagen cross-linking,inhibiting protease activity and inhibiting bacteria.Therefore,PA could be broadly used in the clinical application of treatment and repair of deep caries in the future;for example,PA could promote dentin remineralization,improve resin-dentin bonding durability and improve the dentin acid erosion effect.This application potential of PA arises from several features,firstly,PA can not only promote dentin remineralization on its own or with other remineralizers but also exhibits antibacterial effects,which can inhibit acid production while reducing the formation of cariogenic pathogens and their biofilms.Based on the above features,PA can reduce the incidence of caries disease;thus,PA improves deep caries and long-term effects after treatment.In addition,PA added to adhesives or etch agents can improve the etching and bonding effect of dentin by inducing collagen crosslinking and inhibiting protease activity,thus achieving the ultimate goal of improving the bonding performance of deep caries.This paper summarizes recent progress of research on PA for the treatment and repair of deep caries,including the promotion of dentin remineralization and antibacterial activity as well as the improvement in dentin bonding and acid etching effect,to provide a more comprehensive reference for treating and restoring deep caries in clinical practice.

关 键 词：原花青素 牙再矿化 牙本质粘接剂 龋齿 胶原 酸蚀 交联剂 基质金属蛋白酶 

分 类 号：R78[医药卫生—口腔医学]