eCBTI联合阿戈美拉汀治疗慢性失眠症并发抑郁的疗效  

Effect of e-aid cognitive behavioral therapy combined with agomelatine in the treatment of chronic insomina combined with depression

作　　者：牛仁山[1] 孙威风 NIU Renshan;SUN Weifeng(The First People’s Hospital of Shangqiu,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院,河南商丘476100

出　　处：《中国实用神经疾病杂志》2022年第12期1523-1527,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20191488)。

摘　　要：目的探讨在线失眠认知行为治疗(eCBTI)联合阿戈美拉汀对慢性失眠症并发抑郁患者的疗效。方法采用随机对照研究,将经过评估的慢性失眠症并发抑郁患者随机分成观察组(123例)和对照组(120例),入组后2组均进行问卷调查、量表测试及多导睡眠监测,对照组接受阿戈美拉汀治疗,观察组在对照组基础上加用为期6周的eCBTI,治疗6周后再次对患者进行量表测试及多导睡眠监测。结果相较于基线,观察组及对照组匹兹堡睡眠指数量表(PSQI)、Zung’s抑郁自测量表(SDS)评分及多导睡眠监测参数均有所改善。相较于对照组,观察组PSQI、SDS评分及睡眠监测参数改善更加明显,差异有统计学意义(P<0.05)。结论eCBTI联合阿戈美拉汀对慢性失眠症并发抑郁患者的效果优于单纯的阿戈美拉汀治疗,eCBTI可进一步改善患者失眠的主观感受,优化睡眠结构。Objective To explore the effect of e-aid cognitive behavioral therapy for insomnia(eCBTI) combined with agomelatine on chronic insomina combined with depression.Methods Patients with chronic insomnia complicated with depression were randomly divided into observation group(n=123)and control group(n=120).After enrollment,questionaire survey,scale test and polysomnography were conducted in both groups.The control group received drug treatment,while the observation group received drug treatment and 6-week eCBTI course.Scale test and polysomnography were conducted in both groups again after 6 weeks of treatment.Compared with baseline,Pittsburgh sleep index scale(PSQI),Zung’s self-rating depression scale(SDS)scores and PSG parameters were improved in both the observation group and the control group.Compared with the control group,PSQI,SDS scores and PSG parameters in the observation group were significantly improved,and the difference was statistically significant(P<0.05).Conclusion The effect of eCBTI combined with agomelatine in patients with chronic insomnia complicated with depression is better than that of agomelatine alone.eCBTI can further improve the supervisor perception of patients with insomnia and optimize the sleep structure.

关 键 词：慢性失眠症 抑郁症 在线失眠认知行为治疗 睡眠结构 主观感受 

分 类 号：R749.05[医药卫生—神经病学与精神病学]