小分子热休克蛋白与肿瘤凋亡关系的研究进展  

Advances in the relationships between small heat shock proteins and tumor apoptosis

作　　者：王怡民 李清华[1] Wang Yimin;Li Qinghua(Department of Neurology,Affiliated Hospital of Guilin Medical University,Guangxi Clinical Medical Research Center of Neurological Diseases,Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University,Guilin 541001,China)

机构地区：[1]桂林医学院附属医院神经内科、广西神经系统疾病临床医学研究中心、桂林医学院广西脑与认知神经科学重点实验室,桂林541001

出　　处：《国际医药卫生导报》2023年第3期297-301,共5页International Medicine and Health Guidance News

基　　金：国家自然科学基金资助项目(82160520);中央引导地方科技发展资金项目(桂科ZY21195042);广西科技计划项目(桂科AD17129015);广西神经系统疾病大数据智能云管理重点实验室项目(ZTJ2020005)。

摘　　要：小分子热休克蛋白(small heat shock proteins,sHSPs)是众多热休克蛋白(heat shock proteins,HSPs)中的一大类,包括HSPB1、HSPB5、HSPB6、HSPB8等。近来研究表明,它们在许多信号通路扮演关键角色,这些信号通路与肿瘤的发生、抗放疗和凋亡的抑制有着许多联系,尤其是在肿瘤凋亡方面。本文对sHSPs在肿瘤凋亡途径方面予以综述。Small heat shock proteins(sHSPs)are a large group of many heat shock proteins(HSPs),including HSPB1,HSPB5,HSPB6,and HSPB8.Recent studies have shown that they play key roles in many signaling pathways that have many connections with tumorigenesis,anti-radiation,and apoptosis inhibition,especially in tumor apoptosis.In this paper,the effects of sHSPs on tumor apoptosis pathways are reviewed.

关 键 词：小分子热休克蛋白 肿瘤 凋亡 热诱导 

分 类 号：R730.2[医药卫生—肿瘤]