中老年脑微出血灶发生危险因素分析  

Risk factors of cerebral microbleeds in middle-aged and elderly population

作　　者：张海沙 罗琳[2] 原小军[2] 陈强[2] ZHANG Haisha;LUO Lin;YUAN Xiaojun;CHEN Qiang(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China;Department of Medical Imaging,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院第一附属医院医学影像科

出　　处：《包头医学院学报》2023年第2期20-25,共6页Journal of Baotou Medical College

摘　　要：目的:探讨脑微出血灶(CMBs)发生以及影响CMBs严重程度的危险因素。方法:对本院行MRI常规序列及磁敏感加权成像(SWI)序列检查的1 616例患者进行回顾性分析,根据患者的年龄、性别进行病例匹配,最终将CMBs阳性和阴性患者各668例分别纳入病例组和对照组,比较病例组和对照组之间临床资料的差异。按照CMBs个数,将CMBs阳性患者进一步分为轻度、中度及重度,比较三者临床资料有无差异。结果:病例组与对照组的脑白质稀疏(LA)和腔隙性脑梗死(LI)等差异显著(P<0.05),高血压、年龄与CMBs的发生显著相关(P<0.05)。轻度、中度及重度CMBs患者的高血压、LA及LI级别亦有显著差异(P<0.05)。收缩压、舒张压、平均动脉压、LA以及LI级别与CMBs数目之间存在正相关关系。结论:高血压及年龄是CMBs发生的危险因素,而且CMBs的发生及严重程度与LA和LI的程度紧密关联。Objective:To investigate the occurrence of cerebral microbleeds( CMBs) and risk factors affecting the severity of CMBs. Methods:A retrospective analysis was performed on 1 616 patients who underwent conventional MRI sequence and susceptibility weighted imaging(SWI) examination in our hospital. Patients were matched according to their age and gender, and finally 668 CMBs-positive patients were divided into the case group and 668 CMBs-negative patients into the control group. Clinical data of patients in the two groups were collected, including history of hypertension, diabetes, abnormal lipid metabolism, et al. The differences of clinical data between the case group and control group were statistically compared. According to the number of CMBs, CMBs-positive patients were further divided into the mild, moderate and severe group. The differences of clinical data among the three groups were also compared. Results:There were significant differences in white matter sparsity(LA) and lacunar infarction(LI) between the case group and the control group(P<0.05). Hypertension and age were significantly correlated with the occurrence of CMBs(P<0.05). There were also significant differences on hypertension, LA and LI levels among mild, moderate and severe CMBs patients(P<0.05). Systolic blood pressure, diastolic blood pressure, mean arterial pressure, LA and LI levels were positively correlated with the number of CMBs. Conclusion:Hypertension and age are risk factors to CMBs, and the incidence and severity of CMBs are closely related to the degree of LA and LI.

关 键 词：脑微出血灶 磁敏感加权成像 高血压 危险因素 

分 类 号：R743.34[医药卫生—神经病学与精神病学]