结直肠癌生物标志物的研究进展  

Research progress in biomarkers of colorectal cancer

作　　者：陈夕浪 吴开春 CHEN Xi-lang;WU Kai-chun(Department of Gastroenterology,State Key Laboratory of Cancer Biology,National Clinical Research Center for Digestive Diseases,Xijing Hospital,Air Force Medical University,Shanxi Xian,710032 China)

机构地区：[1]空军军医大学西京医院消化内科,肿瘤生物学国家重点实验室,国家消化系统疾病临床研究中心,陕西西安710032

出　　处：《内科急危重症杂志》2023年第1期1-5,共5页Journal of Critical Care In Internal Medicine

基　　金：国家自然科学基金面上项目(No:82273374)。

摘　　要：结直肠癌(CRC)是严重影响人类健康的恶性疾病之一。约25%的CRC患者在初诊时已经发生远处转移,这类患者预后极差。高预测性能的生物标志物能早期精准检出CRC并精确预测疗效。近年来,多项研究指出炎性标志物、非编码RNA、肠道菌群、循环肿瘤细胞等指标具备CRC诊断及预后预测能力。本文就CRC生物标志物的研究进展进行讨论,以期为CRC的诊治提供思路。Colorectal cancer(CRC)is one of the malignant diseases that has caused huge burdens to human health.About 25%patients have distant metastasis at the time of diagnosis.Unfortunately,metastasis CRC tends to have poor prognosis.Efficacious biomarkers show good performances in detecting CRC and in predicting therapeutic effects.It is an effective approach to improve CRC patients,outcomes.Recently,numerous researches indicated that some indicators can be used as biomarkers for early diagnosis and predictors of prognosis in CRC,such as inflammatory markers,non-coding RNA,gut microbiota,circulating tumor cells.In this review,we summarize the research progress in biomarkers of CRC for the purpose of providing new sights to the diagnosis and treatment of CRC.

关 键 词：结直肠癌 血清生物标志物 炎症生物标志物 非编码RNA 肠道菌群 循环肿瘤细胞 循环肿瘤DNA 

分 类 号：R735.35[医药卫生—肿瘤]