肝动脉灌注榄香烯治疗原发性肝癌的应用价值分析  

Analysis of Application Value of Hepatic Artery Infusion of Elemene in the Treatment of Primary Hepatocellular Carcinoma

作　　者：杨帆 杨军 濮忠建 YANG Fan;YANG Jun;PU Zhongjian(Hai'an Hospital of Traditional Chinese Medicine,Jiangsu Province,Hai'an 226600,China;不详)

机构地区：[1]江苏省海安市中医院,江苏海安226600

出　　处：《中国医学创新》2023年第6期1-7,共7页Medical Innovation of China

摘　　要：目的:研究肝动脉灌注榄香烯治疗原发性肝癌的应用价值。方法:研究工作从2017年7月开始,并在2022年7月完成案例数据采集工作,共收录海安市中医院肿瘤科100例原发性肝癌病例。通过随机数字表法分组,每组50例。对照组采用肝动脉灌注碘化油+洛铂+盐酸表柔比星治疗;研究组通过肝动脉灌注榄香烯乳+洛铂治疗。然后收集并分析患者的治疗质量、肿瘤标志物水平、生存质量、肝功能、免疫功能、复发及不良事件情况等,并对数据进行对比分析。结果:治疗后,研究组治疗质量比对照组更高(P<0.05);治疗后,研究组血清肿瘤标志物指标均比对照组更低(P<0.05);治疗后,研究组生存质量评分比对照组更高(P<0.05);治疗后,研究组肝功能各项指标均低于对照组(P<0.05);治疗后,研究组CD3^(+)、CD4^(+)比对照组均更高(P<0.05);研究组复发率低于对照组(P<0.05);研究组不良事件发生率低于对照组(P<0.05)。结论:在针对原发性肝癌的治疗中,选择榄香烯为患者进行肝动脉灌注治疗能够提高治疗质量,可以有效提高化疗药物治疗效果,并降低化疗药物对患者身体产生的毒副作用,患者病情能够得到更好的控制,肿瘤标志物水平明显降低,生存质量得到改善,机体免疫系统及肝脏功能得到更好的恢复,并有效降低患者出现复发及其他不良事件发生的概率,在动脉灌注治疗中加入榄香烯对于原发性肝癌的治疗具有十分重要的作用,建议在原发性肝癌的临床治疗中予以积极的借鉴和采纳。Objective:To study the application value of hepatic artery infusion of elemene in the treatment of primary hepatocellular carcinoma.Method:The study started in July 2017 and completed case data collection in July 2022.A total of 100 cases of primary hepatocellular carcinoma in the Oncology Department of Hai’an Hospital of Traditional Chinese Medicine were included.They were divided into groups by random number table,50 cases in each group.The control group was treated with hepatic artery infusion of Iodized Oil+Lobaplatin+Epirubicin Hydrochloride.The study group was treated by hepatic artery infusion of Elemene Emulsion+Lobaplatin.Then the data of treatment quality,tumor marker level,quality of life,liver function,immune function,recurrence and adverse events were collected and analyzed,and the data were compared.Result:After treatment,the quality of treatment in study group was higher than that in control group(P<0.05).After treatment,the serum tumor markers in the study group were lower than those in the control group(P<0.05).After treatment,the quality of life in the study group was higher than that in the control group(P<0.05).After treatment,the liver function indexes of the study group were lower than those of the control group(P<0.05).After treatment,CD3^(+)and CD4^(+)in the study group were higher than those in the control group(P<0.05).The recurrence rate of the study group was lower than that of the control group(P<0.05).The incidence of adverse events in the study group was lower than that in the control group(P<0.05).Conclusion:In the treatment of primary hepatocellular carcinoma,elemene can improve the quality of treatment,effectively improve the therapeutic effect of chemotherapy drugs,and reduce the toxic and side effects of chemotherapy drugs on the patient’s body.The patient’s condition can be better controlled,the level of tumor markers can be significantly reduced,the quality of life can be improved,and the immune system and liver function of the body can be better restored,in addition,it

关 键 词：肝动脉灌注 榄香烯 原发性肝癌 肿瘤标志物 生存质量 肝功能 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]