丁苯酞软胶囊治疗急性缺血性脑血管病的药学作用机制研究  

Study on the pharmacological mechanism of butylphthalide soft capsule in the treatment of acute ischemic cerebrovascular disease

作　　者：刘慧琪 LIU Hui-qi(Department of Pharmacy,Dezhou Hospital of Traditional Chinese Medicine,Dezhou 253000,China)

机构地区：[1]山东省德州市中医院西区西药房,253000

出　　处：《中国实用医药》2023年第3期10-13,共4页China Practical Medicine

摘　　要：目的探讨急性缺血性脑血管病患者采用丁苯酞软胶囊治疗的效果。方法选取100例急性缺血性脑血管病患者为研究对象,采用随机数字表法分为对照组和观察组,每组50例。对照组给予常规治疗,观察组在对照组治疗基础上加用丁苯酞软胶囊治疗。比较两组治疗效果、血脂指标、血清炎性因子水平、日常生活活动能力、神经功能缺损程度及不良反应发生情况。结果观察组治疗总有效率为94.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗3个月后,两组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)水平均明显低于本组治疗前,高密度脂蛋白胆固醇(HDL-C)水平明显高于本组治疗前,且观察组LDL-C水平(1.67±0.45)mmol/L、TC水平(3.28±0.41)mmol/L、TG水平(1.53±0.32)mmol/L均明显低于对照组的(2.16±0.51)、(4.27±0.58)、(1.97±0.51)mmol/L,HDL-C水平(1.49±0.32)mmol/L明显高于对照组的(1.35±0.27)mmol/L,差异有统计学意义(P<0.05)。治疗3个月后,两组肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)均明显低于本组治疗前,且观察组TNF-α水平(86.05±19.31)pg/ml、MMP-9水平(58.45±12.31)ng/ml、hs-CRP水平(3.12±0.34)μg/ml低于对照组的(102.33±16.84)pg/ml、(73.22±12.55)ng/ml、(3.67±0.81)μg/ml,差异有统计学意义(P<0.05)。治疗3个月后,两组Barthel指数(BI)评分高于本组治疗前,美国国立卫生研究院卒中量表(NIHSS)评分低于本组治疗前,且观察组BI评分(79.22±3.73)分高于对照组的(56.79±3.81)分,NIHSS评分(13.08±4.39)分低于对照组的(20.39±5.71)分,差异有统计学意义(P<0.05)。对照组仅出现腹泻1例,经系统对症治疗后改善;观察组出现转氨酶轻度升高1例,4周后予以复查,呈正常恢复,两组肾功能经随访正常。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论急性缺血性脑血管病患者采用丁苯酞软胶囊治疗可提�Objective To discuss the effect of butylphthalide soft capsule in the treatment of acute ischemic cerebrovascular disease.Methods A total of 100 patients with acute ischemic cerebrovascular disease were studied,and were divided into control group and observation group by random numerical table,with 50 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with butylphthalide soft capsule on the basis of the control group.Both groups were compared in terms of therapeutic effect,blood lipid index,serum inflammatory factor level,activities of daily living,neurological deficit,and the occurrence of adverse reactions.Results The total effective rate of treatment in the observation group was 94.00%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the levels of low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC)and triglyceride(TG)in both groups were significantly lower than those before treatment in this group,and the level of high-density lipoprotein cholesterol(HDL-C)was significantly higher than that before treatment in this group;the observation group had LDL-C level of(1.67±0.45)mmol/L,TC level of(3.28±0.41)mmol/L,and TG level of(1.53±0.32)mmol/L,which were significantly lower than(2.16±0.51),(4.27±0.58),and(1.97±0.51)mmol/L in the control group;the HDL-C level was(1.49±0.32)mmol/L in the observation group,which was significantly higher than(1.35±0.27)mmol/L in the control group;the differences were statistically significant(P<0.05).After 3 months of treatment,the tumor necrosis factor-α(TNF-α),matrix metalloproteinase-9(MMP-9),and high-sensitivity C-reactive protein(hs-CRP)in both groups were significantly lower than those before treatment in this group;the observation group had TNF-αlevel of(86.05±19.31)pg/ml,MMP-9 level of(58.45±12.31)ng/ml,and hs-CRP level of(3.12±0.34)μg/ml,which were lower than(102.33±16.84)pg/ml,(73.22±12.55)ng/ml,and

关 键 词：急性缺血性脑血管病 丁苯酞软胶囊 血脂指标 炎症因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R969[医药卫生—临床医学]