鞘内输注吗啡用于神经病理性疼痛患者镇痛的效果观察  

Observation on analgesic effect of intrathecal morphine infusion in patients with neuropathic pain

作　　者：周健相 区浩林 李小华 ZHOU Jian-xiang;OU Hao-lin;LI Xiao-hua(Jiangmen Central Hospital,Jiangmen 529000,China)

机构地区：[1]江门市中心医院,529000

出　　处：《中国实用医药》2023年第3期32-35,共4页China Practical Medicine

摘　　要：目的探究神经病理性疼痛患者采用鞘内输注吗啡镇痛的临床效果。方法74例神经病理性疼痛患者,以随机数字表法分为实验组和对照组,每组37例。对照组采用口服氨酚羟考酮治疗,实验组采用鞘内输注吗啡治疗。比较两组镇痛效果、不同时期疼痛评分、不良反应发生情况以及负性情绪评分。结果实验组镇痛总有效率97.30%高于对照组的72.97%,不良反应发生率5.41%低于对照组的29.73%,差异均具有统计学意义(P<0.05)。治疗后24 h、72 h、1周及1个月,实验组患者的疼痛评分分别为(4.05±0.25)、(3.14±0.54)、(2.06±0.36)、(2.47±0.62)分,均低于对照组的(6.04±0.78)、(5.35±0.51)、(4.98±0.18)、(4.52±0.69)分,差异均具有统计学意义(P<0.05)。实验组患者焦虑评分(35.63±4.85)分、抑郁评分(31.69±2.58)分均低于对照组的(56.25±5.12)、(58.24±2.49)分,差异均具有统计学意义(P<0.05)。结论神经病理性疼痛患者采用鞘内输注吗啡治疗,可有效减轻患者疼痛。Objective To investigate the clinical effect of intrathecal morphine infusion in patients with neuropathic pain.Methods A total of 74 patients with neuropathic pain were divided into experimental group and control group according to the random numerical table,with 37 cases in each group.The control group was treated with oral oxycodone and acetaminophen,and the experimental group was treated with intervened with intrathecal morphine infusion.The analgesic effects,pain scores at different periods,occurrence of adverse reactions,and negative emotional score were compared between the two groups.Results The total analgesic efficiency 97.30%of the experimental group was higher than 72.97%of the control group,and the incidence of adverse reactions 5.41%was lower than 29.73%of the control group,and the differences were statistically significant(P<0.05).After 24 h,72 h,1 week and 1 month of treatment,the pain scores of patients in the experimental group were(4.05±0.25),(3.14±0.54),(2.06±0.36)and(2.47±0.62)points,which were lower than(6.04±0.78),(5.35±0.51),(4.98±0.18),and(4.52±0.69)points in the control group,and the differences were statistically significant(P<0.05).The anxiety score(35.63±4.85)points and depression score(31.69±2.58)points in the experimental group were lower than(56.25±5.12)and(58.24±2.49)points in the control group,and the differences were statistically significant(P<0.05).Conclusion Intrathecal morphine infusion in patients with neuropathic pain can effectively relieve the pain of patients.

关 键 词：鞘内输注 吗啡 神经病理性疼痛 镇痛 

分 类 号：R741[医药卫生—神经病学与精神病学]