顺铂热灌注化疗联合肝动脉灌注化疗栓塞术治疗肝细胞癌患者的效果  

Effects of Cisplatin hyperthermic perfusion chemotherapy combined with transcatheter hepatic arterial chemoembolization in treatment of patients with hepatocellular carcinoma

作　　者：柳彬 李智颖 LIU Bin;LI Zhiying(Oncology Department of Jiamusi Tumor and Tuberculosis Hospital,Jiamusi 154002 Heilongjiang,China;Department of Oncology of Hongda Hospital of Jiamusi University,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市肿瘤结核医院肿瘤科,黑龙江佳木斯154002 [2]佳木斯大学宏大医院肿瘤科,黑龙江佳木斯154002

出　　处：《中国民康医学》2023年第3期24-27,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察顺铂热灌注化疗联合肝动脉灌注化疗栓塞术(TACE)治疗肝细胞癌(HCC)患者的效果。方法:选取2017年12月至2019年12月佳木斯中医医院收治的80例原发性中晚期HCC患者进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各40例。对照组行TACE治疗,观察组在对照组基础上联合顺铂热灌注化疗治疗,比较两组肿瘤控制率、治疗前后炎性因子[白细胞介素(IL)-2、IL-4、IL-10、肿瘤坏死因子-α(TNF-α)]水平、血清学指标[甲胎蛋白(AFP)、白蛋白(Alb)、γ-干扰素(IFN-γ)]水平、治疗期间不良反应和并发症发生率。结果:观察组肿瘤控制率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05);治疗后,两组IL-2、IL-4、TNF-α、IFN-γ、AFP水平均低于治疗前,且观察组低于对照组,两组IL-10水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组Alb水平均高于治疗前,但组间比较,差异无统计学意义(P>0.05);两组治疗期间不良反应和并发症发生率比较,差异均无统计学意义(P>0.05)。结论:顺铂热灌注化疗联合TACE治疗HCC患者可提高肿瘤控制率,改善炎性因子和血清学指标水平,效果优于单纯TACE治疗。Objective:To observe effects of Cisplatin hyperthermic perfusion chemotherapy combined with transcatheter hepatic arterial chemoembolization(TACE)in treatment of patients with hepatocellular carcinoma(HCC).Methods:A prospective study was conducted on 80patients with primary advanced HCC admitted to Jiamusi Hospital of Traditional Chinese Medicine from December 2017 to December 2019.They were divided into observation group and control group according to the random number table method,40 cases in each group.The control group was treated with TACE,while the observation group was treated with Cisplatin hyperthermic perfusion chemotherapy on the basis of that of the control group.The tumor control rate,the levels of inflammatory factors[interleukin(IL)-2,IL-4,IL-10,tumor necrosis factor-α(TNF-α)],the serological index levels[alpha-fetoprotein(AFP),albumin(Alb),γ-interferon(IFN-γ)]before and after treatment,and the incidence of adverse reactions and complications during the treatment were compared between the two groups.Results:The tumor control rate of the observation group was 92.50%(37/40),which was higher than 75.00%(30/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-2,IL-4,TNF-α,IFN-γand AFP in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of IL-10 in the two groups were higher than those before treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of Alb in the two groups were higher than those before the treatment,but there was no significant difference between the two groups(P>0.05).There were no significant differences in the incidence of adverse reactions and complications between the two groups(P>0.05).Conclusions:Cisplatin hyperthermic perfusion chemotherapy combined with TACE can improve the tumor control rate,im

关 键 词：顺铂热化疗灌注 肝动脉灌注化疗栓塞 肝细胞癌 肿瘤控制率 炎性因子 不良反应 

分 类 号：R735.7[医药卫生—肿瘤]