盐酸米诺环素联合一次法根管治疗术治疗逆行性牙髓炎患者的效果  

Effects of Minocycline hydrochloride combined with one-time root canal therapy on patients with retrograde pulpitis

作　　者：史万丽 SHI Wanli(Department of Stomatology of Jiulong Dental Clinic,Luoyang 471000 Henan,China)

机构地区：[1]洛阳市九龙口腔门诊部口腔科,河南洛阳471000

出　　处：《中国民康医学》2023年第3期65-68,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察盐酸米诺环素联合一次法根管治疗术治疗逆行性牙髓炎患者的效果。方法:选取2020年1月至2021年1月该院收治的84例逆行性牙髓炎患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各42例。对照组采用一次法根管治疗术治疗,观察组在对照组基础上联合盐酸米诺环素治疗,比较两组临床疗效、治疗前后牙周指数[龈沟出血指数(SBI)、探诊深度(PD)、菌斑指数(PLI)、牙龈指数(GI)]、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)]水平,以及及不良反应发生率。结果:观察组治疗总有效率为95.24%,高于对照组的78.57%,差异有统计学意义(P<0.05);观察组SBI、PD、PLI、GI等牙周指数评分均低于对照组,差异有统计学意义(P<0.05);观察组TNF-α、IL-2水平均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.76%,低于对照组的19.05%,差异有统计学意义(P<0.05)。结论:盐酸米诺环素联合一次法根管治疗术治疗逆行性牙髓炎患者,可提高临床疗效,改善牙周健康,降低炎性因子水平,安全性高,其效果优于单纯一次法根管治疗。Objective:To observe the effect of minocycline hydrochloride combined with one-time root canal therapy on patients with retrograde pulpitis.Methods:A prospective study was conducted on 84 patients with retrograde pulpitis admitted to the hospital from January 2020to January 2021.According to the random number table method,they were divided into control group and observation group,42 cases in each group.The control group was treated with one-time root canal therapy,while the observation group was treated with Minocycline hydrochloride on the basis of that of the control group.The clinical efficacy,the periodontal index levels[gingival sulcus bleeding index(SBI),probing depth(PD),plaque index(PLI),gingival index(GI)],the inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-2(IL-2)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.24%,which was higher than 78.57%in the control group,and the difference was statistically significant(P<0.05).The periodontal index scores of SBI,PD,PLI and GI in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of TNF-αand IL-2 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 4.76%,which was lower than 19.05%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Minocycline hydrochloride combined with one-time root canal therapy in the patients with retrograde pulpitis can improve clinical efficacy,improve the periodontal health,reduce the inflammatory factor levels,and has high safety.Moreover,it is superior to single root canal therapy.

关 键 词：盐酸米诺环素 一次法根管治疗术 逆行性牙髓炎 牙周指数 炎性因子 不良反应 

分 类 号：R781.05[医药卫生—口腔医学]