首发青少年抑郁患者治疗前静息态自发脑电的临床研究  

Clinical study of resting spontaneous eeg in first-episode adolescent depression patients before treatment

作　　者：郑树万 朱丽芳 李晓燕 张海波 苏菲 Zheng Shuwan;Zhu Lifang;Li Xiaoyan;Zhang Haibo;Su Fei(Imaging Department of Zhongshan Third People's Hospital,Zhongshan,Guangdong,528451,China;Nanlang Clinic of Zhongshan Third People's Hospital,Zhongshan,Guangdong 528451,China)

机构地区：[1]广东省中山市第三人民医院,广东中山528451 [2]广东省中山市第三人民医院南朗门诊,广东中山528451

出　　处：《首都食品与医药》2023年第4期32-34,共3页Capital Food Medicine

基　　金：2020年中山市医学科研项目(项目编号:2020J223)。

摘　　要：目的 研究分析首次抑郁症发作的青少年患者治疗前静息态自发脑电的特点.方法 选取2014年3月-2021年7月在中山市第三人民医院门诊行脑电图检查的首发青少年抑郁症治疗前患者59例(抑郁组)及同一时期同龄健康体检青少年42例(对照组)作为研究对象,采用日本光电EEG-1200C型脑电图记录仪,按照国际10-20系统放置16导的头皮记录电极描记处于安静、全身放松状态下的脑电波,比较两组研究对象静息态自发脑电信号特点及脑电图检查结果,包括α波、β波及θ波等的改变及异常率等.结果 发现首发青少年抑郁患者EEG总异常率29%,青少年健康体检对照组总异常率5%,两组的静息态自发脑电图异常率的差异有统计学意义(P<0.05),且在α波前移或泛化、慢波增加这两项异常表现特征上的差异有统计学意义(P<0.05);在α波减弱或慢化、α波不对称、广泛低电压、β波活动增多这些异常特征上的差异均无统计学意义(P>0.05),不同程度抑郁组各亚组的EEG特征及异常情况上的差异亦无统计学意义(P>0.05).结论 首发青少年抑郁患者治疗前静息态自发脑电存在EEG异常,如α波前移或泛化、θ波增多,可为早发现、早干预、早治疗青少年抑郁患者提供辅助检查依据.Objective To study the characteristics of resting spontaneous EEG in adolescent patients with first episode of depression before treatment.Method 59 patients(case group)with the first episode of adolescent depression who underwent EEG examination in our outpatient department from March 2014 to July 2021 before treatment and 42 adolescents of the same age who underwent physical examination at the same time(control group)were selected as the research objects.The EEG recorder of Japan Optoelectronic EEG-1200C was used to record the EEG waves in a quiet and relaxed state with 16 lead scalp recording electrodes placed in accordance with the international 10-20 system,compare the characteristics of resting spontaneous EEG signals and EEG examination results of the two groups of subjects,includingαWaveβSpread The change and abnormal rate of wave,etc.Result It was found that the total abnormal rate of EEG in the first episode of adolescent depression was 29%,and the total abnormal rate in the control group of adolescent health examination was 5%.The difference in the abnormal rate of resting spontaneous EEG between the two groups was statistically significant(P<0.05),and there were statistically significant differences in the two abnormal features ofαwave front shift or generalization and slow wave increase(P<0.05);stayαWeakening or slowing downαWave asymmetry,extensive low voltageβThere was no statistically significant difference in these abnormal characteristics of wave activity increase(P>0.05),and there was no statistically significant difference in EEG characteristics and abnormal conditions of each subgroup of depression groups at different levels(P>0.05).Conclusion There are EEG abnormalities in resting spontaneous EEG in the first episode of adolescent depression before treatment,such asαwave front shift or generalization the wave increases,which provides an auxiliary examination basis for early detection,early intervention and early treatment of adolescent depression patients.

关 键 词：首发 青少年抑郁症 自发脑电 

分 类 号：R749.41[医药卫生—神经病学与精神病学]