长期使用0.1 g·L-1阿托品对青少年近视患者泪液分泌、泪膜稳定性及睑板腺形态的影响  

Effects of long-term use of 0.1 g·L-1 atropine on tear secretion, tear film stability and tarsal gland morphology in myopic adolescents

作　　者：张侠 贺美男 刘琳 史千惠 魏瑞华 ZHANG Xia;HE Meinan;LIU Lin;SHI Qianhui;WEI Ruihua(Eye Hospital of Tianjin Medical University,Tianjin Medical University Eye Institute,School of Optometry and Ophthalmology,Tianjin Medical University,Tianjin 300384,China)

机构地区：[1]天津医科大学眼科医院、眼视光学院、眼科研究所,国家眼耳鼻喉疾病临床医学研究中心天津市分中心,天津市视网膜功能与疾病重点实验室,天津市300384

出　　处：《眼科新进展》2023年第3期195-197,202,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:82070929);天津市教委社科重大项目(编号:2020JWZD20)。

摘　　要：目的 探讨长期使用0.1 g·L-1阿托品对青少年近视患者泪液分泌、泪膜稳定性及睑板腺形态的影响。方法 随机选取2021年12月至2022年3月就诊于天津医科大学眼科医院视光门诊及近视防控门诊的青少年近视患者120例120眼作为研究对象。根据是否使用阿托品将患者分为两组:试验组60例60眼,患者规律使用0.1 g·L-1阿托品滴眼液24个月及以上;对照组60例60眼,患者仅配戴单光框架眼镜且近6个月内未使用人工泪液等药物。收集并比较两组患者眼表疾病指数评分、泪河高度、侵入性泪膜破裂时间、非侵入性首次泪膜破裂时间、非侵入性平均泪膜破裂时间、角膜荧光素染色评分等指标;并进行睑板腺形态评估,包括睑板腺缺失率和睑板腺弯曲腺体个数。结果 试验组患者眼表疾病指数评分低于对照组,差异有统计学意义(P<0.05)。两组患者泪河高度、非侵入性首次泪膜破裂时间、非侵入性平均泪膜破裂时间、侵入性泪膜破裂时间、角膜荧光素染色评分差异均无统计学意义(均为P>0.05)。两组患者上、下眼睑的睑板腺缺失率及总睑板腺缺失率,差异均无统计学意义(均为P>0.05)。两组患者上、下眼睑的睑板腺弯曲腺体个数及总睑板腺弯曲腺体个数差异均无统计学意义(均为P>0.05)。结论 长期使用0.1 g·L-1阿托品不会影响青少年近视患者基础泪液分泌、泪膜稳定性和睑板腺形态。Objective To investigate the effects of long-term use of 0.1 g·L-1atropine eye drops on tear secretion, tear film stability and tarsal gland in adolescents with myopia. Methods Totally 120 patients(120 eyes) who visited the Optometry Clinic and Myopia Prevention and Control Clinic of Tianjin Medical University Eye Hospital from December 2021 to March 2022 were randomly selected. They were divided into two groups based on whether atropine was used or not. In the treatment group, 60 patients(60 eyes) were regularly treated with 0.1 g·L-1atropine eye drops for over 24 months. In the control group, 60 patients(60 eyes) wore single-vision frame glasses and did not use artificial tears or other drugs in the past 6 months. The ocular surface disease index(OSDI), tear meniscus height(TMH), invasive tear break-up time(TBUT), non-invasive first tear break-up time(NIBUTf), non-invasive average tear break-up time(NIBUTav), and corneal fluorescein staining(CFS) score were collected and compared. Morphological evaluation of the tarsal gland was performed, including the tarsal gland dropout ratio and distorted gland number. Results The OSDI score of the treatment group was significantly lower than that of the control group(P<0.05). There was no significant difference in the TMH, NIBUTf, NIBUTav, TBUT and CFS between the two groups(all P>0.05). In addition, there was no significant difference in the tarsal gland dropout ratio and distorted gland number of the upper eyelid, lower eyelid and total tarsal gland area between the two groups(all P>0.05). Conclusion Long-term use of 0.1 g·L-1atropine eye drops does not affect basic tear secretion, tear film stability and tarsal gland morphology in myopic adolescents. What’s more, it can relieve dry eyes.

关 键 词：阿托品 睑板腺 泪液分泌 泪膜稳定性 非侵入性眼表综合分析仪 

分 类 号：R778[医药卫生—眼科]