洛铂术中腹腔浸洗联合腹腔镜手术治疗胃肠肿瘤的临床效果  

Clinical effect of laparoscopic surgery combined with intraoperative Lobaplatin peritoneal lavage in the treatment of gastrointestinal tumors

作　　者：赵传稳 周航 陈志冰[1] ZHAO Chuanwen;ZHOU Hang;CHEN Zhibing(The First Department of General Surgery,Jiujiang NO.1 People's Hospital,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院普外一科,江西九江332000

出　　处：《中国当代医药》2023年第8期88-91,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202211815)。

摘　　要：目的分析洛铂术中腹腔浸洗联合腹腔镜手术治疗胃肠肿瘤的效果。方法回顾性选取2019年1月至2021年5月江西省九江市第一人民医院普外一科收治的80例胃肠肿瘤患者作为研究对象,按照治疗方式不同分为观察组(n=40)和对照组(n=40)。观察组行腹腔镜手术联合术中洛铂腹腔浸润冲洗治疗,对照组行单纯腹腔镜手术。比较两组患者治疗前后生活质量评分、住院时间、住院费用、肿瘤标志物水平[血浆D-二聚体(D-D)、纤维蛋白(原)降解产物(FDP)、抗凝血酶Ⅲ(AT-Ⅲ)]、并发症发生率与半年后疾病复发率。结果治疗前,两组患者生活质量评分、肿瘤标志物水平比较,差异无统计学意义(P>0.05)。治疗后,两组患者的生活质量评分均高于本组治疗前,且观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。观察组住院时间短于对照组,差异有统计学意义(P<0.05)。观察组住院费用低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者肿瘤标志物水平比较,差异无统计学意义(P>0.05);治疗后,两组患者D-D和FDP水平均低于本组治疗前,AT-Ⅲ水平高于本组治疗前,且观察组D-D、FDP低于对照组,AT-Ⅲ高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率、半年后疾病复发率低于对照组,差异有统计学意义(P<0.05)。结论行腹腔镜手术联合术中洛铂腹腔浸润冲洗治疗胃肠肿瘤患者,可有效提高患者的生活质量水平,改善其肿瘤标志物水平,降低并发症率与复发率,促进其康复速度,值得在临床上推广和应用。Objective To analyze the effect of laparoscopic surgery combined with intraoperative Lobaplatin peritoneal lavage in the treatment of gastrointestinal tumors.Methods A total of 80 patients with gastrointestinal tumors admitted to the First Department of General Surgery of Jiujiang NO.1 People's Hospital from January 2019 to May 2021 were selected retrospectively as the research subjects.According to different treatment methods,they were divided into observation group(n=40)and control group(n=40).The observation group was treated with laparoscopic surgery combined with intraoperative Lobaplatin peritoneal lavage,and the control group was treated with laparoscopic surgery.The quality of life scores,hospitalization time,hospitalization expenses,tumor marker levels(plasma D-dimer[D-D],fibrin[proto]degradation products[FDP],antithrombinⅢ[AT-Ⅲ])before and after treatment,complication rate and disease recurrence rate after half a year were compared between the two groups.Results There were no significant differences in quality of life scores and tumor markers between the two groups before treatment(P>0.05).After treatment,the quality of life scores of patients in the two groups were higher than those before treatment,and the quality of life scores in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The length of hospital stay in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The hospitalization cost of the observation group was lower than that of the control group,with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in the levels of tumor markers between the two groups(P>0.05).After treatment,the levels of D-D and FDP in the two groups were lower than those before treatment,the level of AT-Ⅲin the two groups was higher than that before treatment,and the levels of D-D and FDP in the observation group were

关 键 词：洛铂 腹腔浸洗 腹腔镜术 胃肠肿瘤 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]