阿尔茨海默病的发病机制研究进展  

Research progress in pathogenesis of Alzheimer′s disease

作　　者：翟雅莉[1] 王晓明[2] Zhai Yali;Wang Xiaoming(Fifth Outpatient Department,986 Hospital,Xijing Hospital,Fourth Military Medical University,Xi′an 710061,China;Department of Geriatrics,Xijing Hospital,Fourth Military Medical University,Xi′an 710032,China)

机构地区：[1]第四军医大学西京医院九八六医院第五门诊部,西安710061 [2]第四军医大学西京医院老年病科,西安710032

出　　处：《中华老年多器官疾病杂志》2023年第2期139-142,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家重点研发计划(2020YFC2008000)。

摘　　要：阿尔茨海默病(AD)的发生随着人口老龄化的进程加剧而增加,给老年人的健康造成了极大的威胁,已成为全球性重大公共卫生健康问题。因此,积极探讨其发病机制,对AD的早期筛查、预防、诊断及治疗具有非常重要的意义。本文综述了近年来AD相关机制的研究进展,认为年龄是AD发生的最主要的危险因素,β-淀粉样蛋白沉积和tau蛋白高度磷酸化、基因突变、炎症、微血管病变、代谢紊乱、胆碱能系统损伤等因素是AD的重要发病机制。The incidence of Alzheimer′s disease(AD)increases with the aging of population,posing a great threat to the health of the elderly and becoming a major global public health problem.Therefore,active exploration of its pathogenesis is of great significance to its early screening,prevention,diagnosis and treatment.This paper reviews the research progress in the AD-related pathogenesis in recent years,and it is believed that age is the most important risk factor for the development of AD and that factors such asβ-amyloid deposition and high tau phosphorylation,gene mutation,inflammation,microangiopathy,metabolic disorders,and cholinergic system damage constitute the important pathogenesis of AD.

关 键 词：阿尔茨海默病 发病机制 危险因素 

分 类 号：R741.02[医药卫生—神经病学与精神病学]