载脂蛋白E基因的多态性与缺血性脑卒中的发生及其治疗效果的相关研究  

Association of apolipoprotein E gene polymorphism with the occurrence and therapeutic effect of ischemic stroke

作　　者：赵泽宇 张帆 赵建农[1] ZHAO Ze-yu;ZHANG Fan;ZHAO Jian-nong(Hainan General Hospital,Department of Neurosurgery,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China;Hainan General Hospital,Department of Cerebrovascular Diseases,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China)

机构地区：[1]海南省人民医院海南医学院附属海南医院神经外科,海南海口570311 [2]海南省人民医院海南医学院附属海南医院脑血管病科,海南海口570311

出　　处：《海南医学院学报》2023年第5期390-394,共5页Journal of Hainan Medical University

基　　金：海南省重大科技计划项目(ZDKJ202004)。

摘　　要：缺血性脑卒中目前严重影响着人们的生命健康,其发生、发展、治疗效果受多种因素共同影响。随着对缺血性脑卒中疾病的深入研究,人们对其相关致病基因也有了更深一步的了解,其中载脂蛋白E基因型更是近期研究热点,其基因型不仅参与了缺血性脑卒中的发生及发展,同时不同基因型的患者其治疗效果也具有差异性。本文就载脂蛋白E基因的多态性与缺血性脑卒中有关的脂质代谢、动脉粥样硬化的相关性以及不同基因型其溶栓、取栓、降脂等治疗效果的差异性进行系统性综述。At present,ischemic stroke seriously affects people′s life and health,and its occurrence,development and therapeutic effect are affected by many factors.With the deep research on ischemic cerebral apoplexy disease,people have a deeper understanding of its virulence genes.The apolipoprotein E genotype is the research focus recently,its genetic type is not only involved in the occurrence and development of ischemic cerebral apoplexy,but also causes different therapeatic effects.In this paper,we reviewed the relationship between apolipoprotein E gene polymorphism and lipid metabolism and atherosclerosis in ischemic stroke,as well as the differences in the therapeutic effects of thrombolysis,thrombectomy and lipid-lowering among different genotypes.

关 键 词：载脂蛋白E基因 缺血性脑卒中 静脉溶栓 机械取栓 脂质 

分 类 号：R743.3[医药卫生—神经病学与精神病学]