血清CEA、CA199、CA125联合AFP检测对肺癌的诊断价值分析  

The Diagnostic Value of Serum CEA,CA199,CA125 Combined with AFP in Lung Cancer

作　　者：刘晓欣 王营伟 韩晶[1] LIU Xiao-xin;WANG Ying-wei;HAN Jing(Department of laboratory medicine,Anyang People's Hospital,Anyang 455000,Henan Province,China)

机构地区：[1]安阳市人民医院检验科,河南安阳455000

出　　处：《罕少疾病杂志》2023年第3期27-28,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)及甲胎蛋白(AFP)联合检测对肺癌的诊断价值。方法选取2018年1月至2020年12月我院收治的68例肺癌患者作为观察组,68例同期于我院体检的健康体检者作为对照组。所有研究对象均于清晨采血检测血清CEA、CA199、CA125及AFP水平,比较两组间上述指标差异,并绘制ROC曲线,分析CEA、CA199、CA125、AFP单独及联合检测诊断肺癌的价值。结果观察组CEA[(62.89±6.28)ng/mL]、CA199[(135.41±12.18)U/mL]、CA125[(86.79±6.82)U/mL]、AFP水平[(63.87±5.87)ng/mL]高于对照组,差异有统计学意义(P<0.05);绘制ROC曲线显示,血清CEA、CA199、CA125、AFP单独及联合检测诊断肺癌的曲线下面积(AUC)分别为:0.760、0.750、0.721、0.799、0.977,联合检测诊断价值最高。结论血清CEA、CA199、CA125、AFP联合检测在肺癌诊断中价值高,可进一步提高诊断灵敏度、特异度,适用于肺癌早期筛查。Objective To explore the diagnostic value of combined detection of serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)and alpha fetoprotein(AFP)in lung cancer.Methods 68 lung cancer patients admitted to our hospital from January 2018 to December 2020 were selected as the observation group,and 68 healthy people who underwent physical examination in our hospital at the same time were selected as the control group.All the subjects took blood in the early morning to detect the serum levels of CEA,CA199,CA125 and AFP,compared the differences of the above indexes between the two groups,drew the ROC curve,and analyzed the clinical value of CEA,CA199,CA125 and AFP alone and in combination in the diagnosis of lung cancer.Results the observation group’s levels of CEA[(62.89±6.28)ng/ml],CA199[(135.41±12.18)U/ml],CA125[(86.79±6.82)U/ml]and AFP[(63.87±5.87)ng/ml]were significantly higher than control group’s(P<0.05);The ROC curve showed that the AUC of serum CEA,CA199,CA125 and AFP in the diagnosis of lung cancer were 0.760,0.750,0.721,0.799 and 0.977 respectively,combined test has the highest diagnostic value.Conclusion serum CEA,CA199,CA125 and AFP is of high value in the diagnosis of lung cancer.Combined detection can improve the diagnostic sensitivity and specificity,and is suitable for early screening of lung cancer.

关 键 词：肺癌 癌胚抗原 糖类抗原 甲胎蛋白 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]