对比常规放疗与三维适形放射治疗(3D-CRT)乳腺癌的临床疗效、毒副作用  

Comparison of Conventional Radiotherapy and Three-dimensional Conformal Radiotherapy Clinical Efficacy,Toxic and Side Effects and Survival Rate of Breast Cancer Treatment(3D-CRT)

作　　者：张倩 关佳恒 宋旭旭 胡立宏 ZHANG Qian;GUAN Jia-heng;SONG Xu-xu;HU Li-hong(Oncology Department of the 989th Hospital of the Joint Logistics Support Force,Luoyang 471000,Henan Province,China)

机构地区：[1]联勤保障部队第989医院肿瘤科,河南洛阳471000

出　　处：《罕少疾病杂志》2023年第3期34-35,58,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的对比常规放疗与三维适形放射治疗(3D-CRT)乳腺癌的临床疗效、毒副作用。方法选定本院2018年1月至2021年1月住院的90例乳腺癌患者,以随机法将其分组(每组n=45),对比组给予常规放疗治疗,观察组给予3D-CRT治疗,对比两组局部复发率、血清肿瘤标志物、毒副反应总发生率,统计危及器官照射剂量。结果观察组局部复发率(2.22%)低于对比组(22.22%),P<0.05(差异有统计学意义)。观察组治疗后血清糖类抗原199(CA199)、糖类抗原125(CA125)、癌胚抗原(CEA)均低于对比组,P<0.05(差异均具有统计学意义)。观察组毒副反应总发生率(8.89%)低于对比组(28.89%),P<0.05(差异具有统计学意义)。患侧肺V20、患侧肺V30、患侧肺V40、患侧肺V50、左侧心脏V30、左侧心脏V40、左侧心脏V50、分别是(15.28±2.62)cm^(3)、(10.15±3.96)cm^(3)、(1.85±0.62)cm^(3)、(0.54±0.26)cm^(3)、(2.52±1.25)cm^(3)、(2.24±0.99)cm^(3)、(0.45±0.13)cm^(3)。结论3D-CRT可有效抑制乳腺癌患者肿瘤病灶生长,降低局部复发率、血清肿瘤标志物浓度,同时可减少危及器官照射剂量,减轻毒副反应。Objective To compare the clinical efficacy,side effects of conventional radiotherapy and three-dimensional conformal radiotherapy(3D-CRT)for breast cancer.Methods A total of 90 breast cancer patients hospitalized in our hospital from January 2018 to January 2021 were selected and randomly divided into groups(n=45 in each group).The control group was given conventional radiotherapy,the observation group was given 3D-CRT treatment,The local recurrence rate,serum tumor markers,and total incidence of toxic and side effects were compared between the two groups,and the radiation dose to organs at risk was calculated.Results The local recurrence rate in the observation group(2.22%)was lower than that in the control group(22.22%),P<0.05(the difference was statistically significant).After treatment,the serum carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)in the observation group were lower than those in the control group,P<0.05(all differences were statistically significant).The total incidence of adverse reactions in the observation group(8.89%)was lower than that in the control group(28.89%),P<0.05(the difference was statistically significant).V20 of the affected lung,V30 of the affected lung,V40 of the affected lung,V50 of the affected lung,V30 of the left heart,V40 of the left heart,V50 of the left heart,irradiation doses were(15.28±2.62)cm^(3),(10.15±3.96)cm^(3),(1.85±0.62)cm^(3),(0.54±0.26)cm^(3),(2.52±1.25)cm^(3),(2.24±0.99)cm^(3).(0.45±0.13)cm^(3).Conclusion 3D-CRT can effectively inhibit the growth of tumor lesions in breast cancer patients,reduce the concentration of serum tumor markers,and at the same time,it can reduce the radiation dose to organs at risk and reduce toxic and side effects.

关 键 词：三维适形放射治疗 乳腺癌 临床疗效 毒副作用 

分 类 号：R737.9[医药卫生—肿瘤]