乙肝病毒X蛋白对肝细胞癌甲硫氨酸腺苷转移酶1A表达的影响  

Effect of Hepatitis B Virus X Protein on the Expression of Methionine Adenosine Transferase 1A in Hepatocellular Carcinoma

作　　者：刘春莉 周兴悦 张厚亮 LIU Chun-li;ZHOU Xing-yue;ZHANG Hou-liang(Jinghai District Hospital of Tianjin,Tianjin 301600,China)

机构地区：[1]天津市静海区医院免疫科,天津301600

出　　处：《罕少疾病杂志》2023年第3期41-42,60,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨乙肝病毒X蛋白(HBx)对肝细胞癌甲硫氨酸腺苷转移酶1A(MAT1A)表达的影响。方法选取2019年1月至2022年4月期间医院收治的80例乙肝相关性肝细胞癌患者,术中采集患者癌及癌旁组织,采用免疫组化法检测HBx蛋白、HAT1A表达,统计其阳性率,分析HBx蛋白与HTA1A之间相关性。结果肝细胞癌组织患者HBx蛋白与癌旁组织表达比较(P>0.05),但MAT1A阳性表达低于癌旁组织,肝细胞癌组织共同阳性表达高于癌旁组织(P<0.05)。不同年龄、性别、肿瘤直径、肿瘤分化、TNM分期、门静脉癌栓、肝硬化等患者HBx蛋白、MAT1A阳性表达比较(P>0.05);但不同血清甲胎蛋白(AFP)水平患者HBx蛋白、MAT1A阳性表达比较(P<0.05)。采用Spearman等级相关分析,HBx蛋白、MAT1A阳性表达呈负相关性(r=-0.816,P<0.05)。结论乙肝相关性肝细胞癌患者癌组织HBx蛋白、MAT1A阳性表达高,癌组织HBx蛋白与MAT1A表达呈负相关性。Objective To investigate the effect of hepatitis B virus X protein(HBx)on the expression of methionine adenosine transferase 1A(MAT1A)in hepatocellular carcinoma(HCC).Methods a total of 80 patients with hbV-associated hepatocellular carcinoma admitted to our hospital from January 2019 to April 2022 were selected.During the operation,the cancer and adjacent tissues of the patients were collected,and the expression of HBx protein and HAT1A was detected by immunohistochemical method.The positive rate of HBx protein and HTA1A were analyzed.Results The expression of HBx protein in hepatocellular carcinoma tissues was compared with that in para-cancer tissues(P>0.05),but the positive expression of MAT1A was lower than that in para-cancer tissues,and the co-positive expression of MAT1A was higher in hepatocellular carcinoma tissues than that in para-cancer tissues(P<0.05).The positive expressions of HBx protein and MAT1A in patients with different age,gender,tumor diameter,tumor differentiation,TNM stage,portal vein tumor thrombus and cirrhosis were compared(P>0.05).However,the positive expression of HBx protein and MAT1A in patients with different serum AFP levels was compared(P<0.05).Spearman rank correlation analysis showed that positive expression of HBx protein and MAT1A was negatively correlated(R=-0.816,P<0.05).Conclusion The positive expression of HBx protein and MAT1A is high in patients with hepatitis B associated hepatocellular carcinoma,and the expression of HBx protein and MAT1A is negatively correlated.

关 键 词：HBX蛋白 MAT1A 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]