宫颈脱落细胞特殊染色技术筛查宫颈病变效果  

Application effect of special staining technique of cervical exfoliated cells in the screening of cervical lesions

作　　者：王红岩 王宁 刘昊[3] 刘玉玲[1] 宋亚骄 翟若昕 王晓静[1] 汤福想[1] WANG Hongyan;WANG Ning;LIU Hao;LIU Yuling;SONG Yanjiao;ZHAI Ruoxin;WANG Xiaojing;TANG Fuxiang(The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,450014;National Research Institute for Family Planning,Beijing;Queen Mary College of Nanchang University)

机构地区：[1]郑州大学第二附属医院,450014 [2]国家卫生健康委科学技术研究所 [3]南昌大学玛丽女王学院

出　　处：《中国计划生育学杂志》2023年第3期670-674,共5页Chinese Journal of Family Planning

基　　金：国家卫生健康委科学技术研究所(2019HX017)。

摘　　要：目的:探讨宫颈病变筛查的宫颈脱落细胞特殊染色技术的临床应用效果。方法:选择2021年3月-2022年6月在本院及多家医疗中心行宫颈病变筛查的女性共1176例。进行宫颈癌筛查两项,即人乳头瘤病毒(HPV)+液基薄层细胞(TCT)和宫颈脱落细胞特殊染色实验检测,对筛查出的宫颈病变阳性病例,以阴道镜下宫颈活检病理结果为金标准,对宫颈病变筛查中HPV、TCT和宫颈脱落细胞特殊染色实验的临床应用效果对比分析。结果:3种宫颈癌筛查方式检出的阳性病例与病理学检查的一致率TCT检测(40.1%)>宫颈脱落细胞特殊染色实验(28.8%)>HPV检测19.6%(P<0.05)。宫颈脱落细胞特殊染色实验的灵敏度(62.1%)、准确度(80.1%)与TCT检测(53.8%、89.8%)无差异(P>0.05)。结论:宫颈脱落细胞特殊染色试验在宫颈病变筛查中灵敏度、准确度与TCT检测效果相当,且具有便携性高、操作简单、检测快速和经济实用等特点,适合基层宫颈癌筛查。Objective:To explore the clinical application effect of special staining technique of cervical exfoliated cells in the screening of cervical lesions.Methods:A total of 1176 women who underwent the screening of cervical lesions in several medical centers were selected in this study from March 2021 to June 2022.These women received two cervical cancer screening tests,including human papillomavirus(HPV)combined with thinprep cytologic test(TCT)and special staining technique of cervical exfoliated cells for cervical exfoliated cells.Based on the pathological results of cervical biopsy as the gold standard,the comparative analysis of clinical application effect of the HPV,TCT,and special staining technique of cervical exfoliated cells in the screenng of cervical lesions was conducted.Results:The consistent rate of the positive cases detected by TCT(40.1%),by special staining technique of cervical exfoliated cells(28.8%),.and by HPV(19.6%)had decreased gradually(P<0.05).There were no significant differences in the sensitivity(62.1%vs.53.8%)and the accuracy(80.1%vs.89.8%)for screening cervical lesions between the special staining technique of cervical exfoliated cells and TCT(P>0.05).Conclusion:The sensitivity and the accuracy of special staining test of cervical exfoliated cells for screening of cervical lesions are equivalent to those of TCT.Special staining test of cervical exfoliated cells has the characteristics of high portability,simple operation,rapid detection,and economy and practicality,etc,and which as a cervical cancer screening technology is suitable for implementation by the primary level health service agencies.

关 键 词：宫颈病变筛查 宫颈脱落细胞特殊染色技术 液基薄层细胞检测 人乳头瘤病毒检测 效果比较 

分 类 号：R737.33[医药卫生—肿瘤]