细胞焦亡在白血病中的作用及分子机制研究进展  

Progress of the role and molecular mechanism of pyroptosis in leukemia

作　　者：马艳敏(综述) 殷小成(审校)[1] Ma Yanmin;Yin Xiaocheng(Department of Pediatrics,the First Affiliated Hospital of University of South China,Hengyang 421000,China)

机构地区：[1]南华大学附属第一医院儿科,衡阳421000

出　　处：《国际儿科学杂志》2023年第1期57-60,共4页International Journal of Pediatrics

基　　金：国家自然科学基金(31271482);湖南省卫健委2020年度科研立项课题(20201977)。

摘　　要：细胞焦亡是近年来新发现的一种程序性细胞死亡方式。研究发现,细胞焦亡在多种疾病中发挥着重要作用。白血病是一种恶性造血干细胞疾病,严重威胁着儿童的生命健康。大量的研究表明细胞焦亡与白血病的发生发展密切相关,阐明细胞焦亡在白血病中的具体机制,将可能为临床上白血病治疗提供新的手段。该文将对细胞焦亡的分子机制及其在白血病中的研究进展进行综述,以期加深对细胞焦亡机制的理解及为白血病的临床治疗提供一些思路。Pyroptosis is a newly discovered programmed cell death in recent years.The researches show that pyroptosis plays an important role in many diseases.Leukemia is a malignant hematopoietic stem cell disease,which seriously threatens the health and life of children.Numerous studies have shown that pyroptosis is associated with the occurrence and development of leukemia,and elucidation the mechanism of pyroptosis in leukemia will provide a new method of clinical treatment.In this review,in order to enhance the understanding of the mechanism of pyroptosis and provide some ideas for the treatment of leukemia,the molecular mechanism of pyroptosis and its role in leukemia are reviewed.

关 键 词：白血病 细胞焦亡 分子机制 

分 类 号：R733.7[医药卫生—肿瘤]