免疫球蛋白IgG、IgA联合NLR对小儿手足口病的诊断价值  

Diagnostic value of immunoglobulin IgG,IgA combined with NLR in children with hand,foot and mouth disease

作　　者：姚桂华[1] 林世池 YAO Guihua;LIN Shichi(Laboratory of Xiamen Hospital of Traditional Chinese Medicine,Fujian Xiamen 361001)

机构地区：[1]厦门市中医院检验科,福建厦门361001

出　　处：《医学检验与临床》2023年第1期23-26,共4页Medical Laboratory Science and Clinics

摘　　要：目的:分析免疫球蛋白IgG、IgA联合中性粒细胞与淋巴细胞比值(NLR)诊断小儿手足口病的诊断价值。方法:选取2019年12月-2021年12月本院82例小儿手足口病为研究组,另外选取78例健康者为参照组,采集静脉血做血清免疫球蛋白及NLR检测,均接受随访。对比2组患者免疫球蛋白IgG、IgA及NLR水平,分析其对小儿手足口病的诊断价值。绘制受试者工作特征(ROC)曲线分析免疫球蛋白IgG、IgA及NLR水平诊断小儿手足口病发生的效能。结果:2组患者年龄、体质量指数、既往小儿手足口病病史、性别对比无统计学意义(P<0.05),2组患者免疫球蛋白IgG、IgA及NLR水平对比差异有统计学意义(P<0.05),研究组免疫球蛋白IgA及NLR水平高于参照组,免疫球蛋白IgG水平低于参照组(P<0.05)。多因素Logistic回归分析显示,免疫球蛋白IgG、IgA及NLR均是小儿手足口病的独立危险因素(P<0.05)。根据ROC曲线,免疫球蛋白IgG、IgA及NLR水平联合诊断小儿手足口病的诊断的灵敏度、受试者工作特征曲线下面积(AUC)均高于单项诊断(灵敏度:χ^(2)=3.667,P=0.005;χ^(2)=5.647,P=0.004;χ^(2)=7.854,P=0.003;AUC:Z=8.574,P=0.001;Z=4.887,P=0.002;Z=3.145,P=0.001),特异度与单独预测对比差异均无统计学意义(P>0.05)。结论:小儿手足口病免疫球蛋白IgG、IgA及NLR水平表达异常,且免疫球蛋白IgG、IgA联合NLR对小儿手足口病的诊断价值较高。Objective:To analyze the diagnostic value of immunoglobulin IgG,IgA combined with neutrophil lymphocyte ratio(NLR)in the diagnosis of hand,foot and mouth disease in children.Methods:82 children with hand,foot and mouth disease in our hospital from December 2019 to December 2021 were selected as the study group,and 78 healthy people were selected as the reference group.Venous blood was collected for serum immunoglobulin and NLR testing,and all were followed up.The levels of immunoglobulin IgG,IgA and NLR in the two groups were compared,and their diagnostic value in children's hand,foot and mouth disease was analyzed.The receiver operating characteristic(ROC)curve was drawn to analyze the efficacy of immunoglobulin IgG,IgA and NLR in the diagnosis of hand,foot and mouth disease in children.Results:There was no statistical significance,including age,body quality index,previous history of HFMD,and sex comparison the two groups(P<0.05).There was significant difference in the levels of immunoglobulin IgG,IgA and NLR between the two groups(P<0.05).The levels of immunoglobulin IgA and NLR in the study group were higher than those in the reference group,and the level of immunoglobulin IgG was lower than that in the reference group(P<0.05).Multivariate logistic regression analysis showed that immunoglobulin IgG,IgA and NLR were independent risk factors of hand,foot and mouth disease in children(P<0.05).According to ROC curve,the sensitivity of combined diagnosis of immunoglobulin IgG,IgA and NLR in children's hand,foot and mouth disease and the area under the working characteristic curve(AUC)of subjects were higher than those of single diagnosis(sensitivity:χ^(2)=3.667,P=0.005;χ^(2)=5.647,P=0.004;χ^(2)=7.854,P=0.003;AUC:Z=8.574,P=0.001;Z=4.887,P=0.002;Z=3.145,P=0.001),There was no significant difference between specificity and individual prediction(P>0.05).Conclusion:The expression of immunoglobulin IgG,IgA and NLR in children with hand,foot and mouth disease is abnormal,and the combination of immunoglobulin IgG,IgA and

关 键 词：免疫球蛋白 小儿手足口病 诊断价值 灵敏度 

分 类 号：R739.63[医药卫生—肿瘤]