基于静息态功能MRI低频振幅对青少年强迫症脑功能研究  

Brain function study of amplitude of low frequency fluctuation based on resting state functional MRI in adolescent obsessive-compulsive disorder

作　　者：谢荣倩 宋赣军 张道恩 雷洪俊 彭娟 张高峰 XIE Rongqian;SONG Ganjun;ZHANG Dao'en;LEI Hongjun;PENG Juan;ZHANG Gaofeng(Department of Medical Imaging,the Second Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province 563000,China;Department of Medical Imaging,the Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province 563003,China;Department of Psychological Clinic,the Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province 563003,China)

机构地区：[1]遵义医科大学第二附属医院医学影像科,贵州遵义563000 [2]遵义医科大学附属医院医学影像科,贵州遵义563003 [3]遵义医科大学附属医院心理门诊,贵州遵义563003

出　　处：《实用放射学杂志》2023年第1期1-4,共4页Journal of Practical Radiology

基　　金：贵州省基础研究计划(科学技术基金)(黔科合基础-ZK[2021]一般480)。

摘　　要：目的探讨青少年强迫症(OCD)静息态功能磁共振成像(rs-fMRI)大脑自发神经活动异常脑区与强迫症状相关性.方法选取经心理门诊确诊的青少年OCD患者30例作为病例组,同时招募性别、年龄、受教育程度及利手与病例组相匹配的健康志愿者27例作为对照组,2组均采用耶鲁-布朗强迫量表(Y-BOCS)进行强迫症状评估后进行rs-fMRI扫描,对2组rs-fMRI数据进行低频振幅(ALFF)处理,采用Pearson相关分析病例组异常脑区ALFF值与Y-BOCS总分间的相关性.结果2组间性别、年龄及受教育年限无统计学差异(P>0.05),Y-BOCS总分有统计学差异(P<0.05).病例组ALFF值增高脑区:右侧颞中回、眶额下回及左侧额下回三角部;ALFF值降低脑区:右侧中央前回、左侧楔前叶、壳核、枕中回(P<0.05).Pearson相关分析显示左侧楔前叶ALFF值与Y-BOCS总分呈负相关(r=-0.71,P<0.05).结论青少年OCD患者rs-fMRI涉及多个脑区自发神经活动异常,其中左侧楔前叶ALFF值异常可能与强迫症状有关.Objective To investigate the correlation of cerebral spontaneous nerve activity changes and obsessive-compulsive symptoms in adolescent obsessive-compulsive disorder(OCD)in resting state functional magnetic resonance imaging(rs-fMRI).Methods Thirty adolescent patients with OCD were collected as the case group,at the same time,twenty-seven healthy volunteers were recruited as the control group who matched with the case group in gender,age,degree of education and handedness.The obsessivecompulsive symptoms of the two groups were evaluated based on the Yale-Brown obsessive-compulsive scale(Y-BOCS),and then all the participants had received the rs-fMRI scanning,the rs-fMRI data calculated by the amplitude of low frequency fluctuation(ALFF),Pearson correlation analysis was used to analyze the correlation between ALFF value and Y-BOCS total score in the abnormal brain area of the case group.Results There was no statistical difference in gender,age and degree of education between the two groups(P>0.05),but the Y-BOCS total score was significant difference(P<0.05).In the casegroup,the ALFF value increased brain areas include right middle temporal gyrus,inferior orbital frontal gyrus and left inferior frontal gyrus triangle;while the ALFF values decreased in right precentral gyrus,left precuneus,putamen and middle occipital gyrus(P<0.05).Pearson correlation analysis showed that the value of ALFF in the left precuneus was negative correlation with the total score of Y-BOCS(r=-0.71,P<0.05).Conclusion Adolescent OCD patients involves abnormal spontaneous nerve activity in brain regions in rs-fMRI,the changes of the left precuneus ALFF value may be related to obsessive-compulsive symptom.

关 键 词：青少年 强迫症 静息态功能磁共振成像 低频振幅 

分 类 号：R749[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]