首发未服药精神分裂症患者自发脑活动的频率特异性改变  

Frequency-Specific Alterations of Spontaneous Brain Activity in First-Episode Drug-Na?ve Schizophrenia

作　　者：邓丽红 魏巍[1] 乔春霞 殷钰冰 蹇玲琪 李涛 DENG Li-hong;WEI Wei;QIAO Chun-xia;YIN Yu-bing;JIAN Ling-qi;LI Tao(Mental Health Center and Psychiatric Laboratory,the State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China;Affiliated Mental Health Center,Zhejiang University School of Medicine&Hangzhou Seventh People's Hospital,Hangzhou 310013,China)

机构地区：[1]四川大学华西医院心理卫生中心,成都610041 [2]浙江大学医学院附属精神卫生中心杭州市第七人民医院,杭州310013

出　　处：《四川大学学报（医学版）》2023年第2期281-286,共6页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.82001410)和国家自然科学基金重点项目(No.81920108018、No.81630030)资助。

摘　　要：目的探究首发未服药精神分裂症(schizophrenia,SZ)患者自发脑活动的频率特异性改变及其与临床症状的关联。方法采集84例首发未服药SZ患者和94例健康对照的静息态功能磁共振数据,计算slow-2、slow-3、slow-4和slow-5频段的低频振幅(ALFF)和局部一致性(ReHo)。用两独立样本t检验比较ALFF和ReHo的组间差异。用偏相关分析探索SZ组异常ALFF和ReHo与临床症状严重程度的相关性。结果与健康对照相比,SZ组在slow-2、slow-3和slow-4频段小脑上部和蚓部ALFF降低,在slow-4频段左侧颞上回、颞中回和上颞极ALFF增高;在slow-3频段右侧中央后回和中央前回ReHo下降。SZ组slow-4频段的左侧颞上回、颞中回和上颞极ALFF与阳性与阴性症状量表兴奋因子分呈正相关趋势。结论首发未服药SZ患者局部自发脑活动异常具有频率特异性。Objective To investigate frequency-specific alterations of spontaneous brain activity in firstepisode drug-na?ve schizophrenia(SZ) patients and the associations with clinical symptoms. Methods We collected the resting-state functional MRI(rs-fMRI) data from 84 first-episode drug-na?ve SZ patients and 94 healthy controls(HCs)and calculated the amplitude of low-frequency fluctuations(ALFF) and regional homogeneity(ReHo) of four frequency bands, including slow-2, slow-3, slow-4, and slow-5. Two-sample t-tests were used to evaluate the intergroup differences in ALFF and ReHo, while partial correlation analyses were conducted to explore the associations between abnormal ALFF and ReHo and the severity of clinical symptoms in the SZ group. Results Compared with HCs, the SZ group showed reduced ALFF in superior cerebellum and cerebellar vermis across slow-2, slow-3, and slow-4 bands, while increased ALFF was found in left superior temporal gyrus, middle temporal gyrus, and superior temporal pole at slow-4 band.Moreover, reduced ReHo was observed in the right precentral and postcentral gyri at slow-3 band in the SZ group.Additionally, the ALFF of left superior temporal gyrus, middle temporal gyrus, and superior temporal pole in slow-4 band showed a trend of positive correlation with the excited factor score of Positive and Negative Syndrome Scale(PANSS) in the SZ group. Conclusion Our results suggest that local alterations of spontaneous brain activity were frequency-specific in first-episode drug-na?ve SZ patients.

关 键 词：精神分裂症 自发脑活动 频率特异性 低频振幅 局部一致性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]