荧光素钠引导下显微切除术治疗脑胶质瘤患者的效果  

Effects of Fluorescein sodium-guided microsurgery in treatment of brain glioma

作　　者：邱会斌[1] QIU Huibin(Department of Neurosurgery of Anyang Hospital,Anyang 455000 Henan,China)

机构地区：[1]安阳地区医院神经外科,河南安阳455000

出　　处：《中国民康医学》2023年第4期39-42,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察荧光素钠(FLS)引导下显微切除术治疗脑胶质瘤患者的效果。方法:回顾性分析2019年1月至2021年3月该院收治的114例脑胶质瘤患者的临床资料,按照治疗方法不同将其分成观察组和对照组各57例。对照组行常规显微切除术治疗,观察组行FLS引导下显微切除术治疗。比较两组手术全切率、围术期指标(手术时间、住院时间、术中失血量)水平、术前和术后3个月肿瘤标志物[血清癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原15-3(CA15-3)]水平、基质金属蛋白酶-9(MMP-9)水平、血管内皮生长因子(VEGF)水平、健康状态[卡氏评分(KPS)]和并发症发生率。结果:观察组手术全切率为92.98%(53/57),高于对照组的78.95%(45/57),差异有统计学意义(P<0.05);观察组手术时间、住院时间均短于对照组,术中失血量少于对照组,差异有统计学意义(P<0.05);术后3个月,观察组血清CA125、CEA、CA15-3、MMP-9、VEGF水平均低于对照组,差异有统计学意义(P<0.05);术后3个月,观察组KPS评分高于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:FLS引导下显微切除术治疗脑胶质瘤患者可提高手术全切率,改善健康状态,优化围术期指标水平,降低肿瘤标志物、MMP-9和VEGF水平,效果优于常规显微切除术治疗。Objective: To observe effects of Fluorescein sodium(FLS)-guided microsurgery in treatment of brain glioma. Methods:The clinical data of 114 patients with brain glioma admitted to the hospital from January 2019 to March 2021 were retrospectively analyzed. They were divided into observation group and control group according to different treatment methods, 57 cases in each. The control group was treated with conventional microsurgery, while the observation group was treated with FLS-guided microsurgery. The total resection rate, the perioperative indicator levels(operation time, hospitalization time, intraoperative blood loss), the tumor marker levels [serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125), carbohydrate antigen 15-3(CA15-3)], the levels of matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor(VEGF), the health status [Karnofsky score(KPS)], and the incidence of complications were compared between the two groups.Results: The total resection rate of the observation group was 92.98%(53/57), which was higher than 78.95%(45/57) of the control group, and the difference was statistically significant(P<0.05). The operation time and the hospitalization time of the observation group were shorter than those of the control group;the intraoperative blood loss was less than the control group;and the differences were statistically significant(P<0.05). 3 months after the surgery, the levels of serum CA125, CEA, CA15-3, MMP-9 and VEGF in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). 3 months after the surgery, the KPS score of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). However, there was no significant difference in the incidence of complications between the two groups(P>0.05). Conclusions: FLS-guided microsurgery for the patients with brain glioma can improve the total resection rate and the KPS score, improve the levels of pe

关 键 词：荧光素钠 脑胶质瘤 显微切除术 肿瘤标志物 健康状态 

分 类 号：R739.41[医药卫生—肿瘤]