血清CHE、CHOL、ALB水平联合检测在肝硬化诊断中的应用价值  

Application value of combined detection of serum CHE,CHOL and ALB levels in diagnosis of liver cirrhosis

作　　者：张文栋 ZHANG Wendong(Department of Clinical Laboratory of the Second People’s Hospital of Anyang,Anyang 455000 Henan,China)

机构地区：[1]安阳市第二人民医院检验科,河南安阳455000

出　　处：《中国民康医学》2023年第4期135-137,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清胆碱酯酶(CHE)、胆固醇(CHOL)及清蛋白(ALB)水平联合检测在肝硬化诊断中的应用价值。方法:回顾性分析2020年1月至2021年12月该院收治的52例肝硬化患者的临床资料(设为研究组),按照Child-Pugh分级将其分为A级18例、B级20例,C级14例;选取同期50名健康体检者作为对照组,比较对照组与肝硬化患者血清CHE、CHOL、ALB水平,不同肝功能分级患者血清CHE、CHOL、ALB水平,并分析CHE、CHOL、ALB单项及联合检测的阳性检出率。结果:研究组CHE、CHOL、ALB水平均低于对照组,差异有统计学意义(P<0.05);C级患者的CHE、CHOL、ALB水平均低于A级、B级,且B级低于A级,差异有统计学意义(P<0.05);不同分级肝硬化患者CHE、CHOL、ALB水平单项检测及联合检测的阳性检出率均高于对照组,差异均有统计学意义(P<0.05)。结论:肝硬化患者CHE、CHOL、ALB水平均降低,CHE、CHOL、ALB水平联合检测对肝硬化具有较高的诊断价值。Objective:To analyze application value of combined detection of serum cholinesterase(CHE),cholesterol(CHOL)and albumin(ALB)levels in diagnosis of liver cirrhosis.Methods:The clinical data of 52 patients with liver cirrhosis admitted to this hospital from January 2020to December 2021 were retrospectively analyzed(set as study group).According to the Child-Pugh classification,they were divided into 18 cases of grade A,20 cases of grade B and 14 cases of grade C.50 healthy subjects were selected as control group.The levels of serum CHE,CHOL and ALB between the control group and the liver cirrhosis group as well as among the patients with different liver function grades were compared.Further,the positive detection rates of CHE,CHOL and ALB single detection and combined detection were compared.Results:The levels of CHE,CHOL and ALB in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CHE,CHOL and ALB in the patients of grade C were lower than those of grade A and grade B,those of the patients of grade B were lower than those of grade A,and the differences were statistically significant(P<0.05).The positive detection rates of single and combined detection of CHE,CHOL and ALB levels:grade C>grade B>grade A>control group,and the differences were statistically significant(P<0.05).Conclusions:The levels of CHE,CHOL and ALB in the patients with liver cirrhosis are decreased,and the combined detection of CHE,CHOL and ALB has a high diagnostic value for liver cirrhosis.

关 键 词：肝硬化 肝功能 胆碱酯酶 胆固醇 清蛋白 

分 类 号：R575.2[医药卫生—消化系统]