微波消融对比射频消融治疗结直肠癌肝转移瘤的荟萃分析  

Efficacy of microwave ablation versus radiofrequency ablation in the treatment of colon cancer liver metastases:a meta-analysis

作　　者：蓝东媚 黄小准 冉义洪 徐林 陈栋 殷鑫 车旭 赵建军 毕新宇 王树滨[4] Lan Dongmei;Huang Xiaozhun;Ran Yihong;Xu Lin;Chen Dong;Yin Xin;Che Xu;Zhao Jianjun;Bi Xinyu;Wang Shubin(Shantou University Medical College,Shantou 515041,China;Department of Hepatobiliary Surgery,National Cancer Center,Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China;Department of Hepatobiliary Surgery,National Cancer Center,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Oncology,Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research,Cancer Institute,Peking University Shenzhen Hospital,Shenzhen-Peking University-Hong Kong University of Science and Technology Medical Center,Shenzhen 518036,China)

机构地区：[1]汕头大学医学院,汕头515041 [2]国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院深圳医院肝胆外科,深圳518116 [3]国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院肝胆外科,北京100021 [4]北京大学深圳医院肿瘤科,深圳市胃肠肿瘤转化研究重点实验室,深圳北京大学香港科技大学肿瘤研究所,深圳518036

出　　处：《中华肝胆外科杂志》2023年第2期129-134,共6页Chinese Journal of Hepatobiliary Surgery

基　　金：深圳市科技创新委员会项目(ZDSYS20190902092855097、KCXFZ20200201101050887、GJHZ20200731095207023);深圳市"医疗卫生三名工程"项目(SZSM202011010)。

摘　　要：目的通过荟萃分析探究结肠癌肝转移瘤(CRLM)局部消融的最佳治疗方法。方法系统检索PubMed、Web of Science、Embase、CNKI以及Cochrane Library数据库,检索时间为建库至2022年8月22日。通过纳入和排除标准筛选出比较微波消融(WMA)和射频消融(RFA)治疗CRLM的文献。并使用Review Manager 5.3软件对围手术期结局和生存数据进行统计汇总及分析。结果共纳入5篇回顾性研究,总样本量648例,其中WMA组316例(48.8%),RFA组332例(51.2%)。荟萃分析结果显示,WMA组的局部复发率低于RFA组,两组间差异有统计学意义(P<0.05)。WMA组患者的1、2年疾病无进展生存期优于RFA组,两组间差异有统计学意义(1年:P=0.04,HR=1.77,95%CI:1.04~3.02;2年:P=0.02,HR=1.60,95%CI:1.09~2.35)。结论对于CRLM的治疗,WMA在局部控制率和1、2年疾病无进展生存期方面优于RFA。Objective To explore the best treatment for local ablation of colon cancer liver metastases(CRLM)by meta-analysis.Methods The electronic databases of PubMed,Web of Science,Embase,CNKI and the Cochrane Library were searched from the establishment to August 22,2022,and studies that report outcomes with comparison between microwave ablation(WMA)and radiofrequency ablation(RFA)in CRLM treatment were selected by inclusion and exclusion criteria.Furthermore,the perioperative and survival data were statistically summarized and analyzed by Review Manager 5.3 software.Results A total of 5 retrospective studies were included with a total sample size of 648 cases,including 316 cases(48.8%)in the WMA group and 332 cases(51.2%)in the RFA group.The results of meta-analysis showed that locoregional recurrence rate in WMA group was significantly lower than that in RFA group.The 1-year and 2-year disease-free survival(DFS)of the WMA group was significantly better than that of the RFA group with HR of 1.77(P=0.04,95%CI:1.04-3.02)and 1.60(P=0.02,95%CI:1.09-2.35),respectively.Conclusion The local control rate and 1-year and 2-year DFS of WMA were superior to RFA.

关 键 词：结直肠肿瘤 肝转移瘤 微波消融 射频消融 荟萃分析 

分 类 号：R735.34[医药卫生—肿瘤]